DECONTAMINATION OF PLATELET CONCENTRATES

研究的总体目标是确定一个系统， 净化血小板浓缩物 期望的方法 会降低病毒感染和细菌性败血症的风险 与血小板浓缩物的治疗用途有关。 本 对捐献的血液进行筛查并不能检测出所有潜在的 传染性污染物。 因此，重要的是要找到一个 使血液制品非特异性非传染性的方法。 我们打算展示我们的能力， 血小板浓缩物中的动物病毒。 我们会研究 灭活处理对1）总血小板的影响 通过测量血小板计数作为 2）血小板对聚集剂的反应; （3）荧光抗体法测定血小板活化。 这项研究有可能在商业上有用， 保护了大约500万到700万单位的血小板 每年输血。

The overall objective of the research is to define a system for decontaminating platelet concentrates. The desired method would reduce the risk of viral infection and bacterial sepsis associated with therapeutic use of platelet concentrates. Present screening of donated blood will not detect all potentially infectious contaminants. Therefore it is important to find a means of rendering blood products non-specifically non-infectious. We propose to demonstrate our ability to inactivate a model animal virus in platelet concentrates. We will examine the effects of the inactivation treatment on 1) gross platelet morphology by measuring platelet count as a function of inactivation time; 2) response of platelets to aggregating agents; and 3) platelet activation by fluorescent antibody assay. This research has the potential to be commercially useful in safeguarding the estimated 5 to 7 million units of platelets transfused annually.