DECONTAMINATION OF PLATELET CONCENTRATES

浓缩血小板的净化

• 批准号: 3501200
• 负责人: GARY P WIESEHAHN
• 金额: $ 5万
• 依托单位: ADVANCED GENETICS RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1988-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3501200
• 关键词: biotechnology; immunofluorescence technique; platelet aggregation; platelet transfusion; virus cytopathogenic effect

The overall objective of the research is to define a system for decontaminating platelet concentrates. The desired method would reduce the risk of viral infection and bacterial sepsis associated with therapeutic use of platelet concentrates. Present screening of donated blood will not detect all potentially infectious contaminants. Therefore it is important to find a means of rendering blood products non-specifically non-infectious. We propose to demonstrate our ability to inactivate a model animal virus in platelet concentrates. We will examine the effects of the inactivation treatment on 1) gross platelet morphology by measuring platelet count as a function of inactivation time; 2) response of platelets to aggregating agents; and 3) platelet activation by fluorescent antibody assay. This research has the potential to be commercially useful in safeguarding the estimated 5 to 7 million units of platelets transfused annually.

研究的总体目标是定义一个系统

项目成果

Photochemical inactivation of viruses and bacteriophage in plasma and plasma fractions.

• 发表时间: 1992
• 期刊: Blood cells
• 作者: P. Morel;L. Lin;G. Wiesehahn;L. Corash

Use of 8-methoxypsoralen and long wavelength ultraviolet radiation for decontamination of platelet concentrates.

使用 8-甲氧基补骨脂素和长波紫外线辐射对浓缩血小板进行净化。

• DOI: 10.1117/12.137506
• 发表时间: 1992
• 期刊: Blood cells
• 作者: Corash,L;Lin,L;Wiesehahn,G
• 通讯作者: Wiesehahn,G