REAL TIME OPTICAL FEEDBACK CONTROL OF LASER LITHOTRIPSY

描述（改编自申请人摘要）： 拟议的研究计划是进一步发展这项技术 在第一阶段展示了激光器的自动实时反馈控制 碎石术 迄今为止的体外结果显示出相当大的希望， 利用在光发射期间产生的特征性瞬时光发射， 用于激光快速自动反馈控制的脉冲激光碎石术 能量输送 结果是一种可以显着减少 激光损伤健康软组织的风险，同时保持良好的 碎石效果。 对这种设备的需求越来越大。 很明显，临床上使用的激光脉冲能量已经增加， 最坚硬的石头。 此外，这样的设备将是无价的， 在直视有问题的条件下（例如在 胆管树）。 第二阶段工作的具体目标是：1）纳入反馈 控制装置转换为商用（或研究用）脉冲染料激光器 碎石机，2）证明这种碎石机的有效性和安全性提高 在猪中进行的一系列体内研究中的“智能”装置，以及3） 根据第2项的结果和输入建立最终设计规范 来自临床医生用户和激光制造商。

DESCRIPTION (Adapted from applicant's abstract): The objective of the proposed research plan is to further the development of the technology demonstrated in Phase I for automated real-time feedback control of laser lithotripsy. In vitro results to date have shown considerable promise for utilizing the characteristic prompt optical emissions generated during pulsed laser lithotripsy for the rapid automatic feedback control of laser energy delivery. The result is a technique which can significantly reduce the risk of laser injury to healthy soft tissue while maintaining good stone fragmentation efficacy. The need for such a device is increasingly evident as laser pulse energies used clinically have increased in order to treat the hardest stones. Further, such a device would be invaluable under conditions where direct vision is problematic (such as occurs in the biliary tree). The specific aims of the Phase II effort are: 1) incorporate the feedback control device into a commercial (or investigational) pulsed dye laser lithotriptor, 2) demonstrate the efficacy and improved safety of this "smart" device in a series of in vivo studies performed in pigs, and 3) establish final design specifications based on results of item 2 and input from clinician users and the laser manufacturer(s).