LARYNGEAL ENDOSCOPE WITH CALIBRATED SIZING FUNCTION

描述（逐字摘自申请人摘要）：喉视频内窥镜检查 与频闪检查相结合现在已成为临床评估 喉的功能是发出声音。目前正在对视频图像进行评估 仅限于主观视觉判断，可能会导致效果减弱 可靠性。一种能够对图像进行尺寸校准的方法，从而 重要的声音参数的量化，将大大提高 频闪视频内窥镜的临床和研究能力。因此， 拟议项目的主要目标是调查可行性 开发基于激光的投影系统，用于尺寸校准 喉视频内窥镜图像。更长远的目标是发展 广泛适用于上呼吸道柔性内窥镜检查的技术 （包括喉部）。 近期的重点将是开发基于光学的物体尺寸系统 用于柔性光纤经鼻鼻咽镜。第一阶段的任务是 执行的工作包括： (1) 开发参考光束的小型化设计 输送通道兼容小口径和灵活性要求 鼻咽镜，(2) 指定参考光束激光器的要求 与视频频闪操作兼容的照明源，(3) 量化此类系统可实现的物体测量精度，以及 (4) 为适合的完整系统进行初步工程设计 用于临床研究。第二阶段的工作将包括：（1）建设 校准内窥镜系统的完整临床原型，以及 (2) 马萨诸塞州眼耳医院对该系统进行了广泛的临床测试 医务室（MEEI）。 拟议的商业应用： 专为喉部定制的用户友好型校准系统的市场潜力 据估计，美国有数百台类似的系统 更普遍使用上呼吸道（包括喉部）的柔性内窥镜检查有潜力 全球市场销量高达数千台。 后者市场反映了大 在常规临床实践中使用此类示波器的耳鼻喉科医生数量。

DESCRIPTION (Verbatim from the Applicant's Abstract): Laryngeal videoendoscopy combined with stroboscopy is now a mainstay for clinically assessing how the larynx functions to produce voice. Evaluation of the video imagery is currently limited to subjective visual judgments that can result in diminished reliability. A method enabling dimensional calibration of the images, and thus quantification of important vocal parameters, would greatly enhance the clinical and research capabilities of videoendoscopy with stroboscopy. Thus, the main goal of the proposed project is to investigate the feasibility of developing a laser-based projection system for dimensional calibration of laryngeal videoendoscopic images. The longer-term objective is to develop technology that is widely applicable to flexible endoscopy of the upper airway (including larynx). The near-term focus will be to develop an optical-based object sizing system for a flexible fiberoptic transnasal nasopharyngoscope. The Phase I tasks to be performed include: (1) developing a miniaturized design for a reference beam delivery channel compatible with the small caliber and flexibility required of a nasopharyngoscope, (2) specifying requirements for a reference beam laser illumination source compatible with videostroboscopic operation, (3) quantifying the object measurement accuracy achievable with such a system, and (4) developing a preliminary engineering design for a complete system suitable for clinical investigations. The Phase II effort would entail: (1) construction of a complete clinical prototype of the calibrated endoscope system, and (2) extensive clinical testing of the system at the Massachusetts Eye and Ear Infirmary (MEEI). PROPOSED COMMERCIAL APPLICATION: The market potential for a user-friendly calibration system customized for laryngeal video-stroboscopy is estimated to be several hundred units in the U.S. Similar systems for more general use flexible endoscopy of the upper airway (including larynx) have a potential worldwide market of up to several thousand units. The latter market reflects the large number of ototolaryngologists that use such scopes in routine clinical practice.