MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

该提案要求为更换Varian XL提供资金- Varian VXR-300超导高分辨率200 NMR FT NMR。 这一仪器将满足对步行的关键需求 1H和13 C光谱、宽带能力和2D NMR。 主要用户群包括来自该部门的教师 药物化学和化学。 卡萨迪博士会解释 结构和研究化学和分子 生物活性天然产物的药理学。 博格博士和 富克斯将研究复杂天然产物的全合成 具有抗肿瘤等生物活性。 伯恩医生会 研究药物与DNA和RNA模板的相互作用。 博士Chang将在体外研究DNA烷基化的化学过程 以及烷基化寡核苷酸的化学性质。 施瓦布医生会 探讨关键酶的作用机理和立体化学 包括脂肪酸代谢和脱水的过程 反应.

This proposal requests funding for replacement of a Varian XL- 200 NMR with a Varian VXR-300 superconducting high resolution FT NMR. This instrument would meet critical needs for walk-on 1H and 13C spectroscopy, broad-band capabilities, and 2D NMR. The major user group consists of faculty form the Department of Medicinal Chemistry and Chemistry. Dr. Cassady will elucidate the structures and study the chemistry and molecular pharmacology of bioactive natural products. Dr. Boger and Dr. Fuchs will study the total synthesis of complex natural products with antitumor and other biological activity. Dr. Byrn will examine the interaction of drugs with DNA and RNA templates. Dr. Chang will study the chemistry of alkylation of DNA in vitro and the chemistry of alkylated oligonucleotides. Dr. Schwab will explore the mechanism and stereochemistry of key enzymatic processes including metabolism of fatty acids and dehydration reactions.