MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

该提案要求为更换瓦里安XL提供资金- 用VARIAN VXR-300超导高分辨率的200核磁共振 傅立叶变换核磁共振。这台仪器将满足人们对跑车的迫切需求 1H和13C波谱、宽带能力和2D核磁共振。 主要的用户群由来自系的教师组成 药物化学与化学。卡萨迪博士将澄清 化合物的结构及其化学和分子研究 生物活性天然产物的药理学。博格博士和博格博士。 富克斯将研究复杂天然产物的全合成 具有抗肿瘤等生物活性。伯恩博士会 检查药物与DNA和RNA模板的相互作用。 张博士将在体外研究DNA烷基化的化学 以及烷基化寡核苷酸的化学。施瓦布博士将 探索关键酶的作用机理和立体化学 包括脂肪酸代谢和脱水在内的过程 反应。

This proposal requests funding for replacement of a Varian XL- 200 NMR with a Varian VXR-300 superconducting high resolution FT NMR. This instrument would meet critical needs for walk-on 1H and 13C spectroscopy, broad-band capabilities, and 2D NMR. The major user group consists of faculty form the Department of Medicinal Chemistry and Chemistry. Dr. Cassady will elucidate the structures and study the chemistry and molecular pharmacology of bioactive natural products. Dr. Boger and Dr. Fuchs will study the total synthesis of complex natural products with antitumor and other biological activity. Dr. Byrn will examine the interaction of drugs with DNA and RNA templates. Dr. Chang will study the chemistry of alkylation of DNA in vitro and the chemistry of alkylated oligonucleotides. Dr. Schwab will explore the mechanism and stereochemistry of key enzymatic processes including metabolism of fatty acids and dehydration reactions.