ADVANCING BIOMEDICAL RESEARCH & TRAINING IN PUERTO RICO

推进生物医学研究

• 批准号: 3514070
• 负责人: ANNE D FRAME
• 金额: $ 6.19万
• 依托单位: INTER AMERICAN UNIVERSITY/PUERTO RICO
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-01-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3514070
• 关键词: Puerto Rico; anthelmintics; climate; communicable disease control; communicable disease diagnosis; disease reservoirs; epidemiology; epizootiology; feces analysis; field study; health education; health surveys; host organism interaction; human subject; medicinal plants; middle childhood (6-11); milk; minority institution research support; nutrient bioavailability; rural area; serology /serodiagnosis; water pollution

Fasciola hepatica is a parasite causing a liver disease in both man and cattle in Puerto Rico. This increase in this parasitism warrants investigations aimed at understanding this parasite cycle and introducing measures of control and prevention. The proposed investigations are directed towards accomplishing these goals through the following: To analyze on a regional basis the known prevalence of F. hepatica in cattle across the island. To determine the prevalence of F. hepatica in P.R. in humans and goats. To locate the possible sources of human infection of F. hepatica. To determine the ecological factors that contribute to the spread and incidence of F. hepatica on the farms. To determine the effects of concurrent infections of F. hepatica with other parasites commonly found in cattle such as Cotylophoron cotylophorum and Haemonchus contortus as a means of biological control. Molluscicidal assay of several plants revealed Solanaceae to be toxic to L. cubensis snails. The water and the methanol extracts of S. mammosum fruits were toxic for 5 percent and 95 percent of the snail population at 25 ppm. Analysis of the methanolic extract showed the glycosidic steroid alkaloids solasonine and solamargine to be the active products, 100 percent mortality of snails at 10 ppm. Preliminary structure-activity relationship studies suggested a class of glycosidic steroids to be molluscicidal to various parasites transmitting snail species. Other structurally simple amines were shown to be less active.

肝片形吸虫是一种寄生虫，可引起人和牛的肝脏疾病 在波多黎各。 这种寄生虫的增加值得进行调查 了解这种寄生虫循环并引入控制措施， 预防 拟议的调查旨在实现 通过以下方式实现这些目标：在区域基础上分析已知 流行F.在全岛的牛身上发现了肝炎 确定 流行F.肝脏疾病在人类和山羊身上。 为了找到可能的 人感染F.肝。 确定生态因子 导致F.在农场里的肝。 到 确定并发感染F.肝与其他 常见于牛的寄生虫，如牛粪蝇， 捻转血矛线虫作为生物防治手段。 几种植物的杀螺试验表明茄科植物对L. 古巴蜗牛 S. 乳木果 在25 ppm时，对5%和95%的蜗牛种群有毒。 对甲醇提取物的分析表明， 茄果苷和茄边碱为活性产物，死亡率100%， 蜗牛在10 ppm。 初步构效关系研究表明， 一类对各种寄生虫具有杀软体动物作用的糖苷甾体 传播蜗牛物种。 其他结构简单的胺被证明是 不那么活跃。