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ADVANCING BIOMEDICAL RESEARCH & TRAINING IN PUERTO RICO

推进生物医学研究

基本信息

批准号：
3565606
负责人：
ANNE D FRAME
金额：
$ 16.56万
依托单位：
INTER AMERICAN UNIVERSITY/PUERTO RICO
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
起止时间：
1978-01-01 至 1991-07-31
项目状态：
已结题

项目摘要

The proposed research program is designed to investigate areas of current bio-medical importance and at the same time provide Puerto Rico students with the opportunity to acquire research skills. The directorate of Inter American University of Puerto Rico supports the objectives of the planned research and the goals of the Minority Biomedical Research Support Program. The proposed projects are: 1) Synthesis and Biological Activity of Azaoxspi-ranes; New chiral spirohetherocyclic compounds are synthesized and tested for cell membrane activity. Particular emphasis will be given to the stereochemistry-activity relationship. 2) Opportunistic Parasites and Their Control by Polyamine Inhibition; A survey of a segment of the animal population in Puerto Rico for presence of Pneumocystis carinii and Cryptosporidium spp. will be conducted. The role of polyamine inhibition as a means of control will be explored. 3) An Instrument for Epidemiological Studies on Alzheimer's Disease in a Hispanic Population; Development of an instrument and conducting an epidemiological study to assess incidence of Alzheimer's disease in a sample of the Hispanic population in Puerto Rico. 4) Airborne Mutagens as Contaminents of Water Reservoirs; A relationship between airborne mutagens and mutagens found in water reservoirs in Puerto Rico. 5) Snails Hosts of Human Infecting Parasites; Study of the genetics of Biomphalaria glabrata susceptibility to Schistosoma mansoni. 6) Bacteriological Quality and Pathogenic Potential of Selected Puerto Rican Foods; This investigator will correlate the presence of several food-borne pathogens with the increasing prevalence of gastrointestinal illnesses in Puerto Rico. 7) The Associate Investigators project is: Receptor - Ion Flux and Electrophysical Studies. Here using electrophysical experiments, the positive modulation of cholinergic receptors is studied. These investigators are prepared to fulfill their research commitments and meet the MBRS goals and thus make a contribution to biomedical science through research and training of students who will want to pursue research careers.

拟议的研究计划旨在调查目前生物医学的重要性，同时提供波多黎各 Rico学生有机会获得研究技能。的波多黎各美洲大学董事会支持计划研究的目标和少数民族生物医学研究支持计划。拟开展的项目有：1）合成与生物活性新的手性螺杂环化合物合成并测试细胞膜活性。特别重点是立体化学活性关系 2)昆虫寄生虫及其防治多胺抑制;动物一部分的调查波多黎各人群中是否存在卡氏肺孢子虫，隐孢子虫属类将进行。多胺的作用将探讨抑制作为一种控制手段。 3)一个老年痴呆症流行病学研究仪器一个西班牙裔人口;一个工具的发展和进行一项评估阿尔茨海默病发病率的流行病学研究在波多黎各的西班牙裔人口样本中。 4)机载致突变物作为水库污染物;一种关系空气中的诱变剂和水库中的诱变剂之间的关系在波多黎各。 5)钉螺感染人体寄生虫的研究光滑双脐螺对稻瘟病易感性的遗传学研究曼氏血吸虫6)细菌学质量和致病性选定的波多黎各食品的潜力;本研究员将将几种食源性病原体的存在与在波多黎各，胃肠道疾病的发病率不断上升。 7)助理研究员的项目是：受体-离子通量和电物理学研究。这里使用电物理实验，研究了胆碱能受体的正调节。这些研究人员准备完成他们的研究承诺和实现MBRS目标，从而做出贡献通过研究和培训学生，都想从事研究工作

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Forty minutes of experience increase the weight and RNA content of cerebral cortex in periadolescent rats.

四十分钟的体验会增加青春期大鼠的体重和大脑皮层的 RNA 含量。

DOI：
10.1002/dev.420190604
发表时间：
1986
期刊：
Developmental psychobiology
影响因子：
2.2
作者：
Ferchmin,PA;Eterovic,VA
通讯作者：
Eterovic,VA

Characterization of the antitumor activity of a polyantigenic immunomodulator (PAI): I--Utilization of cimetidine and cyclosporine A.

多抗原免疫调节剂 (PAI) 抗肿瘤活性的表征：I--西咪替丁和环孢菌素 A 的利用。

DOI：
发表时间：
1989
期刊：
Boletin de la Asociacion Medica de Puerto Rico
影响因子：
0
作者：
Ríos-Olivares,E;Orraca,ZM;Carrasco-Canales,JA;Alvarado,L;Marchand,AM;Colón,JI
通讯作者：
Colón,JI

Experience affects cortical but not subcortical polyamines.

经验影响皮质但不影响皮质下多胺。