ADVANCING BIOMEDICAL RESEARCH & TRAINING IN PUERTO RICO

拟议的研究计划旨在调查以下领域 目前生物医学的重要性，同时为波多黎各提供 RICO学生有机会获得研究技能。这个 波多黎各美洲大学理事会支持 计划研究的目标和研究的目标 少数民族生物医学研究支持计划。 建议的项目是：1)合成和生物活性 新的手性螺环化合物为 合成并检测细胞膜活性。特例 将重点放在立体化学-活性 两性关系。2)机会性寄生虫及其防治 多胺抑制；动物部分的调查 波多黎各人群中存在卡氏肺孢子虫和 隐孢子虫。将会进行。多胺的作用 将探索抑制作为一种控制手段。3)一个 年阿尔茨海默病流行病学研究工具 西班牙裔人口；乐器和指挥的发展 评估阿尔茨海默病发病率的流行病学研究 在波多黎各的西班牙裔人口样本中。4)机载 作为水库污染源的诱变剂；关系 水库中发现的空气诱变剂和诱变剂之间的关系 在波多黎各。5)人类感染寄生虫的钉螺宿主； 光肩星天牛对白粉病的感病遗传研究 曼氏血吸虫。6)细菌学性质和致病性 精选波多黎各食品的潜力；这位调查员将 几种食源性病原体的存在与 波多黎各的胃肠道疾病日益流行。 7)副研究员项目是：受体-离子通量和 电物理研究。这里使用的是电物理实验， 研究了胆碱能受体的正向调节作用。 这些调查人员准备完成他们的研究 承诺和实现MBRS目标，从而作出贡献 通过研究和培养学生对生物医学科学 会想要从事研究事业。

The proposed research program is designed to investigate areas of current bio-medical importance and at the same time provide Puerto Rico students with the opportunity to acquire research skills. The directorate of Inter American University of Puerto Rico supports the objectives of the planned research and the goals of the Minority Biomedical Research Support Program. The proposed projects are: 1) Synthesis and Biological Activity of Azaoxspi-ranes; New chiral spirohetherocyclic compounds are synthesized and tested for cell membrane activity. Particular emphasis will be given to the stereochemistry-activity relationship. 2) Opportunistic Parasites and Their Control by Polyamine Inhibition; A survey of a segment of the animal population in Puerto Rico for presence of Pneumocystis carinii and Cryptosporidium spp. will be conducted. The role of polyamine inhibition as a means of control will be explored. 3) An Instrument for Epidemiological Studies on Alzheimer's Disease in a Hispanic Population; Development of an instrument and conducting an epidemiological study to assess incidence of Alzheimer's disease in a sample of the Hispanic population in Puerto Rico. 4) Airborne Mutagens as Contaminents of Water Reservoirs; A relationship between airborne mutagens and mutagens found in water reservoirs in Puerto Rico. 5) Snails Hosts of Human Infecting Parasites; Study of the genetics of Biomphalaria glabrata susceptibility to Schistosoma mansoni. 6) Bacteriological Quality and Pathogenic Potential of Selected Puerto Rican Foods; This investigator will correlate the presence of several food-borne pathogens with the increasing prevalence of gastrointestinal illnesses in Puerto Rico. 7) The Associate Investigators project is: Receptor - Ion Flux and Electrophysical Studies. Here using electrophysical experiments, the positive modulation of cholinergic receptors is studied. These investigators are prepared to fulfill their research commitments and meet the MBRS goals and thus make a contribution to biomedical science through research and training of students who will want to pursue research careers.