ADVANCING BIOMEDICAL RESEARCH & TRAINING IN PUERTO RICO

拟议的研究计划旨在调查 目前生物医学的重要性，同时提供波多黎各 Rico学生有机会获得研究技能。 的 波多黎各美洲大学董事会支持 计划研究的目标和 少数民族生物医学研究支持计划。 拟开展的项目有：1）合成与生物活性 新的手性螺杂环化合物 合成并测试细胞膜活性。 特别 重点是立体化学活性 关系 2)昆虫寄生虫及其防治 多胺抑制;动物一部分的调查 波多黎各人群中是否存在卡氏肺孢子虫， 隐孢子虫属类将进行。 多胺的作用 将探讨抑制作为一种控制手段。 3)一个 老年痴呆症流行病学研究仪器 一个西班牙裔人口;一个工具的发展和进行 一项评估阿尔茨海默病发病率的流行病学研究 在波多黎各的西班牙裔人口样本中。 4)机载 致突变物作为水库污染物;一种关系 空气中的诱变剂和水库中的诱变剂之间的关系 在波多黎各。 5)钉螺感染人体寄生虫的研究 光滑双脐螺对稻瘟病易感性的遗传学研究 曼氏血吸虫6)细菌学质量和致病性 选定的波多黎各食品的潜力;本研究员将 将几种食源性病原体的存在与 在波多黎各，胃肠道疾病的发病率不断上升。 7)助理研究员的项目是：受体-离子通量和 电物理学研究。 这里使用电物理实验， 研究了胆碱能受体的正调节。 这些研究人员准备完成他们的研究 承诺和实现MBRS目标，从而做出贡献 通过研究和培训学生， 都想从事研究工作

The proposed research program is designed to investigate areas of current bio-medical importance and at the same time provide Puerto Rico students with the opportunity to acquire research skills. The directorate of Inter American University of Puerto Rico supports the objectives of the planned research and the goals of the Minority Biomedical Research Support Program. The proposed projects are: 1) Synthesis and Biological Activity of Azaoxspi-ranes; New chiral spirohetherocyclic compounds are synthesized and tested for cell membrane activity. Particular emphasis will be given to the stereochemistry-activity relationship. 2) Opportunistic Parasites and Their Control by Polyamine Inhibition; A survey of a segment of the animal population in Puerto Rico for presence of Pneumocystis carinii and Cryptosporidium spp. will be conducted. The role of polyamine inhibition as a means of control will be explored. 3) An Instrument for Epidemiological Studies on Alzheimer's Disease in a Hispanic Population; Development of an instrument and conducting an epidemiological study to assess incidence of Alzheimer's disease in a sample of the Hispanic population in Puerto Rico. 4) Airborne Mutagens as Contaminents of Water Reservoirs; A relationship between airborne mutagens and mutagens found in water reservoirs in Puerto Rico. 5) Snails Hosts of Human Infecting Parasites; Study of the genetics of Biomphalaria glabrata susceptibility to Schistosoma mansoni. 6) Bacteriological Quality and Pathogenic Potential of Selected Puerto Rican Foods; This investigator will correlate the presence of several food-borne pathogens with the increasing prevalence of gastrointestinal illnesses in Puerto Rico. 7) The Associate Investigators project is: Receptor - Ion Flux and Electrophysical Studies. Here using electrophysical experiments, the positive modulation of cholinergic receptors is studied. These investigators are prepared to fulfill their research commitments and meet the MBRS goals and thus make a contribution to biomedical science through research and training of students who will want to pursue research careers.