MOLECULAR DYNAMICS PHOSPHORIMAGING SYSTEM

该提案代表了一项协调努力，以满足 大约150名从事分子科学研究的研究人员 生物或蛋白质化学，需要灵敏、快速的定量 对依赖于检测放射性信号的技术进行分析。 该请求得到了由60名调查人员组成的主要用户组的支持 谁会使用这些工具。适当的制度支持有 已承诺用于技术顾问，将仪器放置在 这两个网站将方便所有使用 为购买外围数据提供辅助资金的工具 处理工作站和软件，并将 仪器到外围计算机进行异地数据存储 和操控。维护和维护仪器的计划， 合理使用它们的时间表，以及无资金支持的初级用户访问权限 已经提供了调查人员。这些文书将被视为 大学分子资源核心的一部分，将被管理 由乔治·亚伯拉罕博士领导的咨询委员会， 研究副院长兼医学教授芭芭拉博士 伊格列夫斯基博士，微生物学和免疫学教授兼主席。 马丁·戈洛夫斯基，生物学教授兼主席，弗雷德·谢尔曼博士， 生物化学教授兼主席特里·普拉特博士 生物化学。这些仪器在分子生物学中的应用 大学和医学院的设施将对其大有裨益 调查人员，将显著减少对 放射性化学品和放射自显影技术，并将提供 所有科学家都拥有一套极高精度的数据分析系统， 到目前为止还没有以任何形式出现在这个主要的研究中心。

The proposal represents a coordinated effort to fill the needs of approximately 150 investigators who undertake research in molecular biology or protein chemistry and require sensitive, rapid quantitative analysis of techniques which rely for detection of a radioactive signal. The request is supported by a primary user group of sixty investigators who would use these instruments. Appropriate institutional support has been committed for technical consultants, placement of the instruments at two sites which would be convenient for all faculty who would use the instruments, provision of ancillary funds for purchase of peripheral data processing work-stations and software, and for networking the instruments to the peripheral computers for off-site data storage and manipulation. Plans for upkeep and maintenance of the instruments, scheduling of their judicious use, and access for junior unfunded investigators, have been provided. The instruments will be considered as part of the University's molecular resources core and will be administered by the advisory committee headed by Dr. George Abraham, Associate Dean for Research and Professor of Medicine, Dr. Barbara Iglewski, Professor and Chair of Microbiology and Immunology, Dr. Martin Gorovksy, Professor and Chair of Biology, Dr. Fred Sherman, Professor and Chair of Biochemistry, and Dr. Terry Platt, Professor of Biochemistry. The addition of these instruments to the Molecular Biology facility at the University and Medical School will be of great benefit to its investigators, will markedly diminish the need for and waste from radioactive chemicals and autoradiographic techniques, and will provide all scientists with a system for data analysis of excellent precision which has hitherto not been present in any form at this major research center.