DEC VAX 11/780 MOLECULAR MODELING SYSTEM

这一提议构成了获得计算和图形的努力 支持现代生物分子结构和 阿古隆研究所的分子生物学小组。我们申请资金用于 购买DEC VAX 11/780，配备适当的外围设备，包括打印机、 绘图仪、新一代廉价磁盘和磁带驱动器，以及 交互式图形系统，如Evans和Sutherland彩色图片 系统330。 这一设施将使大量的现代计算工具可用 研究分子生物学和生物分子结构的科学家。 购置该设备将发挥关键作用的项目 包括：基于结构的蛋白质定点突变； 多肽激素和蛋白质的结构、力学和动力学， 基于结构的tRNA分析物的设计和合成；基因结构， 下丘脑激素基因的调控和序列比较； 核糖核蛋白颗粒的结构和功能研究 抄写。 目前，没有计算机或交互图形功能 Agouron和其他地方的计算机设施受到严格限制 只有少数研究人员可以使用。

This proposal constitutes an effort to obtain computing and graphics facilities necessary for the support of a modern biomolecular structure and molecular biology group at the Agouron Institute. We request funds for the purchase of a DEC VAX 11/780 with adequate peripherals, including printer, plotter, and new generaton inexpensive disk and tape drives, as well as an interactive graphics system such as the Evans and Sutherland Color Picture System 330. This facility will make modern computing tools available to a large number of scientists involved in molecular biology and biomolecular structure. Projects for which acquisition of this equipment will play a pivotal role include: structurally based site specific mutagenesis of proteins; structure, mechanics and dynamics of peptide hormones and proteins, structurally based design and systhesis of tRNA analyogs; gene structure, regulation and sequence comparisons of hypothalamic hormone genes; structure and function studies of ribonucleoprotein particles involved in transcription. At present, there is no computer or interactive graphics capability at the Agouron, and computer facilities elsewhere are severely restricted and available to only a few researchers.