PURCHASE OF A NUCLEAR MAGNETIC RESONANCE SPECTROMETER

资金来自生物医学研究支持共享 购买核磁共振仪的仪器计划 质谱仪，如Magnachem A-200（质子为200 MHz）。 这 仪器将取代多核Varian XL-100仪器， 在过去的12年里一直是部门的主力核磁共振光谱仪。 的 XL-100在1970年是最先进的，但现在它不仅不符合 高场仪器的性能，但由于其年龄，一些 更换零件越来越难找到。 虽然本质上 廉价，延迟，技术人员寻找零件的时间，以及由此产生的 仪器停机时间增加到阻碍我们研究的程度。 新的文书在技术上大大改进了 XL-100，并将允许快速测定光谱在适度 高场常规基础上，并与用户的欢迎程度 友善 该工具将在日常工作中发挥重要作用， 十多个教师研究小组的研究计划，在 俄勒冈州大学，其中许多人目前由美国国立卫生研究赠款资助。 直接受益于这种新的NMR收购的研究领域 光谱仪包括合成和机械有机化学， 多种生物物理探针的设计、合成和应用 分子，酶反应机制的研究，以及对 模型酶反应的机理。 所有这些项目都涉及 新的有机分子的合成和核磁共振光谱分析是主要的 这些程序的新物质的表征方法。

Funds are requested from the Biomedical Research Support Shared Instrumentation Program for the purchase of a nuclear magnetic resonance spectrometer such as the Magnachem A-200 (200 MHz for protons). This instrument will replace a multinuclear Varian XL-100 instrument which has been the department workhorse NMR spectrometer over the past 12 years. The XL-100 was state-of-the-art in 1970, but now it not only does not match the performance of higher field instruments, but because of its age, some replacement parts are becoming difficult to locate. Although inherently inexpensive, the delays, technician time to locate parts, and resulting instrument down time are increasing to a level impeding our research. The new instrument constitutes a significant technical improvement over the XL-100 and will permit the rapid determination of spectra at moderately high field on a routine basis and with a welcome degree of user friendliness. The instrument will play an essential role in the day-to-day research programs of more than ten faculty research groups at the University of Oregon, many of whom are currently funded by NIH grants. Areas of research directly benefiting from acquisition of this new NMR spectrometer include synthetic and mechanistic organic chemistry, the design, synthesis and application of a variety of biophysical probe molecules, the study of enzyme reaction mechanisms, and the study of the mechanisms of model enzyme reactions. All of these programs involve the synthesis of new organic molecules and NMR spectral analysis is the chief method of characterization of new substances for these programs.