PURCHASE OF A NUCLEAR MAGNETIC RESONANCE SPECTROMETER

购买核磁共振波谱仪

• 批准号: 3519126
• 负责人: JOHN F KEANA
• 金额: $ 12万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1985-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519126
• 关键词: chemical synthesis; enzyme model; nuclear magnetic resonance spectroscopy

Funds are requested from the Biomedical Research Support Shared Instrumentation Program for the purchase of a nuclear magnetic resonance spectrometer such as the Magnachem A-200 (200 MHz for protons). This instrument will replace a multinuclear Varian XL-100 instrument which has been the department workhorse NMR spectrometer over the past 12 years. The XL-100 was state-of-the-art in 1970, but now it not only does not match the performance of higher field instruments, but because of its age, some replacement parts are becoming difficult to locate. Although inherently inexpensive, the delays, technician time to locate parts, and resulting instrument down time are increasing to a level impeding our research. The new instrument constitutes a significant technical improvement over the XL-100 and will permit the rapid determination of spectra at moderately high field on a routine basis and with a welcome degree of user friendliness. The instrument will play an essential role in the day-to-day research programs of more than ten faculty research groups at the University of Oregon, many of whom are currently funded by NIH grants. Areas of research directly benefiting from acquisition of this new NMR spectrometer include synthetic and mechanistic organic chemistry, the design, synthesis and application of a variety of biophysical probe molecules, the study of enzyme reaction mechanisms, and the study of the mechanisms of model enzyme reactions. All of these programs involve the synthesis of new organic molecules and NMR spectral analysis is the chief method of characterization of new substances for these programs.

向生物医学研究支持共享基金申请资金 购买核磁共振仪器计划 光谱仪，例如 Magnachem A-200（质子为 200 MHz）。 这 仪器将取代多核 Varian XL-100 仪器，后者具有 过去 12 年来一直是部门的主力核磁共振波谱仪。 这 XL-100在1970年是最先进的，但现在它不仅无法与 性能较高的现场仪器，但由于其年代久远，一些 更换零件变得越来越难找到。 虽然本质上 便宜，延迟，技术人员找到零件的时间，以及由此产生的 仪器停机时间正在增加到阻碍我们研究的水平。 新仪器相对于现有仪器进行了重大技术改进 XL-100 可以在中等温度下快速测定光谱 常规性高，受到用户欢迎 友善。 该仪器将在日常工作中发挥重要作用 十多个教师研究小组的研究项目 俄勒冈大学，其中许多目前由 NIH 拨款资助。 直接受益于购买这种新型 NMR 的研究领域 光谱仪包括合成和机械有机化学， 多种生物物理探针的设计、合成及应用 分子、酶反应机制的研究以及 模型酶反应的机制。 所有这些计划都涉及 新型有机分子的合成和NMR谱分析是主要 这些程序的新物质表征方法。