ELECTRON SPIN RESONANCE SPECTROMETER

申请资金用于购买Bruker ESP 300-10/7 ESR谱仪。 该光谱仪将显著改善 俄勒冈州大学化学系的ESR能力。 目前，该部内有一个瓦里安E-3 光谱仪，1966年购买（主要用作教学 仪器），以及1981年获得的Varian E线光谱仪。 格里菲斯教授大量使用E线光谱仪 我们不能支持所有的项目，我们不能支持所有的项目。 在 此外，仪器变得越来越困难和昂贵 因为瓦里安不再提供零部件、附件 或服务. 所要求的ESP 300-10/7光谱仪是最先进的， 通用且易于操作的仪器。 的 光谱仪和所需的配件将在广泛的应用中投入使用 各种与健康有关的研究项目。 具体来说，这些 包括以下步骤： 教授Keana：新型顺磁性分子的表征 设计用于生物物理学研究和用作对比度增强 用于全身磁共振成像的试剂。 教授Branchaud：自由基探针在酶研究中的应用 反应. 教授Finke：电化学和光化学研究 辅酶介导的电子转移反应的性质 B12 教授格里菲斯：自旋标记脂质的ESR研究， 了解脂质-蛋白质相互作用。 教授von Hippel：E. 使用氮氧自旋的大肠杆菌转录终止蛋白rho 标记为Cys-202。 其他拟议的研究包括： 教授Page：A study of the site symmetry changes of the顺磁 离子在多组分氧化物的溶胶-凝胶合成中的应用。 教授里士满：ESR作为非晶表面缺陷的探针 硅和锗。 教授泰勒：十九电子有机金属化合物的表征 配合物

Funds are requested for the acquisition of a Bruker ESP 300-10/7 ESR spectrometer. This spectrometer will significantly improve the ESR capabilities of the University of Oregon Chemistry Department. Currently there exist within the Department a Varian E-3 spectrometer, purchased in 1966 (used primarily as a teaching instrument), and a Varian E-line spectrometer acquired in 1981. The E-line spectrometer is used heavily by Professor Griffith's group and cannot support all of the projects proposed here. In addition, the instrument is becoming more difficult and expensive to maintain because Varian no longer provides parts, accessories, or service. The requested ESP 300-10/7 spectrometer is the most advanced, versatile and easily operated instrument available today. The spectrometer and requested accessories will be put to use in a wide variety of health-related research projects. Specifically, these include: Prof. Keana: Characterization of novel paramagnetic molecules designed for biophysical studies and for use as contrast enhancing agents for whole body magnetic resonance imaging. Prof. Branchaud: The use of radical probes to investigate enzyme reactions. Prof. Finke: An electrochemical and photochemical investigation of the nature of electron transfer reactions mediated by Coenzyme B12. Prof. Griffith: ESR studies of spin labeled lipids directed at understanding lipid-protein interactions. Prof. von Hippel: A study of the mechanism of action of the E. coli transcription termination protein rho using nitroxide spin labeled Cys-202. Other proposed research includes: Prof. Page: A study of the site symmetry changes of paramagnetic ions in the sol-gel synthesis of multicomponent oxides. Prof. Richmond: ESR as a probe of surface defects in amorphous silicon and germanium. Prof. Tyler: Characterization of nineteen-electron organometallic complexes.