X-RAY MICROANALYSIS AND IMAGE PROCESSING SYSTEM

X射线显微分析和图像处理系统

• 批准号: 3519129
• 负责人: DIANE L. HATCHELL
• 金额: $ 15.66万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1985-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519129
• 关键词: cornea; cornea disorder; electrolytes; electron probe spectrometry; eye bank /preservation; eye pharmacology; image processing; keratoplasty; scanning electron microscopy

Application is made by a group of vision researchers to obtain support for the acquisition of a state-of-the-art energy dispersive x-ray microanalytical and image processing system. The system would be used to update a scanning electron microscope already used on a shared basis in the Department of Ophthalmology. This new instrumentation is needed to enable members of the group to do quantitative microanalysis of alterations in extracellular and intracellular electrolytes in ocular tissues (e.g., during preservation of corneal tissue for transplantation, in pathological conditions and following treatment with various drugs). Image processing capabilities are needed to allow for precise quantitation (e.g., of the rate of corneal neovascularization under various conditions, the rate of corneal wound healing in normal and diabetic animals treated with various drugs and compounds, and the size and shape of regenerated ocular cells). The availability of this new instrumentation will facilitate research efforts leading to a better understanding of the mechanisms involved in sight-threatening pathological conditions.

一组视觉研究人员提出申请， 获取最先进的能量色散X射线 微量分析和图像处理系统。 该系统将用于 更新已经在共享基础上使用的扫描电子显微镜， 眼科部。 需要这种新的仪器， 小组的成员做定量微观分析的变化， 眼组织中的细胞外和细胞内电解质（例如， 在用于移植的角膜组织保存期间，在病理学上， 条件和用各种药物治疗后）。 图像处理 需要允许精确定量的能力（例如，的 各种条件下的角膜新生血管形成率， 在用各种药物治疗的正常和糖尿病动物中的角膜伤口愈合 药物和化合物，以及再生眼细胞的大小和形状）。 这种新仪器的可用性将促进研究 为更好地了解参与的机制所作的努力 威胁视力的病理状况。