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Enhanced molybdenum cluster based materials for biomedical optical oxygen sensing.

用于生物医学光学氧传感的增强型钼簇基材料。

基本信息

批准号：
EP/R006393/1
负责人：
Olga Efremova
金额：
$ 12.84万
依托单位：
University of Hull
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FR006393%2F1
关键词：
Enhanced molybdenum cluster based materials

项目摘要

Oxygen concentration in biological tissue is a unique marker that can be used to establish or monitor pathological conditions of patients such as cancer or inflammation. Unlike pulse oximetry widely used in medical practice, oxygen sensors based on the quenching of luminescence by oxygen is a technique that can provide rapid indication of the local oxygen concentration with a resolution down to microscale region which is determined by the size of the optical fibre substrate used. This technique can provide immediate information on the concentration of oxygen within the small area of an organ or a tissue of critically ill patients (e.g. during an operation or during endoscopic examination of such organs as lungs, gastrointestinal tract, urinary system etc), which can be used to find out the exact location of a disease focus or else to monitor the healing process during treatment. Optical oxygen sensors are quite common for general use (i.e. in non-biological conditions), while this technology is currently only being developed within UK and worldwide for biomedical use . There is a particular need for highly sensitive (to allow for miniaturisation) and biocompatible materials to make significant progress in the direction of sensors for biological conditions. The overall scientific goal of this project is thus to develop biocompatible and robust materials for use in oxygen sensing within biological media. Recently the PI has developed a range of metal cluster complexes that demonstrate high potential for luminescence-based oxygen sensing applications. Specifically, the proof-of-concept studies demonstrate that, even without optimisation, materials based on these complexes have sensitivity to oxygen sensing comparable to the state-of -the art materials. Moreover, this compounds are based on cheap starting materials that do not show any significant toxicity and are highly photo-stable. As such, these moieties are far more advanced luminophores for biomedical oxygen sensing than any other materials that are currently under consideration in the research community (e.g. precious metal complexes, quantum dots, organic dyes). To advance the state of the art in the area of biomedical oxygen sensing, this project (i) will use these recently developed metal cluster complexes as precursors to generate a library of biocompatible materials with high oxygen sensing capacity and (ii) will evaluate the potential of these new materials in medical oxygen sensing.

生物组织中的氧浓度是一种独特的标志物，可用于确定或监测患者的病理状况，例如癌症或炎症。与医学实践中广泛使用的脉搏血氧仪不同，基于氧猝灭发光的氧传感器是一种可以提供局部氧浓度的快速指示的技术，其分辨率低至微尺度区域，该分辨率由所使用的光纤基板的尺寸确定。该技术可以提供关于危重患者的器官或组织的小区域内的氧浓度的即时信息（例如，在手术期间或在诸如肺、胃肠道、泌尿系统等的器官的内窥镜检查期间），其可以用于找出疾病病灶的确切位置或在治疗期间监测愈合过程。光学氧传感器在一般用途（即在非生物条件下）中非常常见，而该技术目前仅在英国和全球范围内开发用于生物医学用途。特别需要高度敏感（以允许固化）和生物相容性材料，以在用于生物条件的传感器的方向上取得重大进展。因此，该项目的总体科学目标是开发生物相容性和坚固的材料，用于生物介质中的氧传感。最近PI已经开发了一系列的金属簇合物，表现出基于发光的氧传感应用的高潜力。具体而言，概念验证研究表明，即使没有优化，基于这些复合物的材料对氧传感的敏感性也与最先进的材料相当。此外，该化合物基于廉价的起始材料，其不显示任何显著的毒性并且是高度光稳定的。因此，这些部分是比研究界目前正在考虑的任何其他材料（例如贵金属络合物，量子点，有机染料）更先进的生物医学氧传感发光体。为了推进生物医学氧传感领域的最新技术水平，该项目（i）将使用这些最近开发的金属簇络合物作为前体，以生成具有高氧传感能力的生物相容性材料库，（ii）将评估这些新材料在医用氧传感中的潜力。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis.

DOI：
10.1002/chem.201804663
发表时间：
2018-11
期刊：
Chemistry
影响因子：
0
作者：
Ekaterina V. Svezhentseva;Yuri A. Vorotnikov;A. Solovieva;T. Pozmogova;I. Eltsov;A. Ivanov;D. V. Evtushok-D.-V.
通讯作者：
Ekaterina V. Svezhentseva;Yuri A. Vorotnikov;A. Solovieva;T. Pozmogova;I. Eltsov;A. Ivanov;D. V. Evtushok-D.-V.

23-Electron Octahedral Molybdenum Cluster Complex [{Mo 6 I 8 }Cl 6 ] -

23-电子八面体钼簇合物 [{Mo 6 I 8 }Cl 6 ] -

DOI：
10.1021/acs.inorgchem.7b02760
发表时间：
2017
期刊：
Inorganic Chemistry
影响因子：
4.6
作者：
Vorotnikova N
通讯作者：
Vorotnikova N

Single-domain antibody C7b for address delivery of nanoparticles to HER2-positive cancers.

DOI：
10.1039/d0nr04899b
发表时间：
2020-10
期刊：
Nanoscale
影响因子：
6.7
作者：
Yuri A. Vorotnikov;E. D. Novikova;A. Solovieva;D. Shanshin;A. Tsygankova;D. N. Shcherbakov;O. Efremova;M. Shestopalov
通讯作者：
Yuri A. Vorotnikov;E. D. Novikova;A. Solovieva;D. Shanshin;A. Tsygankova;D. N. Shcherbakov;O. Efremova;M. Shestopalov

Octahedral molybdenum cluster as a photoactive antimicrobial additive to a fluoroplastic.

八面体钼簇作为氟塑料的光活性抗菌添加剂。