Construction of the Rosalind Franklin Institute Hub

罗莎琳德·富兰克林研究所中心的建设

• 批准号: EP/R029288/1
• 负责人: Neil Phimister
• 金额: $ 516.3万
• 依托单位: Science and Technology Facilities Council
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FR029288%2F1
• 关键词: Construction; Rosalind; Franklin; Institute; Hub

The Life Sciences sector forms a key part of the UK economy: it employs over 220,000 people, contributes significantly to GDP and UK balance of trade, and is crucial for developing leading-edge treatments for patients. It is underpinned by the UK's world-leading research base in the health and life sciences. Many key research breakthroughs are, in turn, enabled by advances in engineering and physical sciences (EPS) research - which provide ever more sophisticated instrumentation and methods to support the study of living organisms (from microbes to plants, animals and the human body) and biological processes (including both disease pathology and drug action).R&D across all parts of this ecosystem - from fundamental understanding to applied research to product development - is crucial for the delivery of long-term economic growth and continued advances in agriculture, food security, healthcare and public health. Historic models of innovation have often been linear, involving a degree of serendipity. Disruptive technologies and scientific breakthroughs will be accelerated if physical scientists, engineers, life scientists and industry work together, and at scale. This is the domain of the Rosalind Franklin Institute (RFI): with a focal point (Hub) at Harwell Science and Innovation Campus, linked to formal Spokes in leading HEIs across the UK, it will integrate complementary expertise from academia and industry to create a national centre of excellence for methods development at the convergence of the physical and life sciences. The RFI will develop disruptive next-generation imaging technologies that will enable step changes in our understanding of cell and disease biology, and the non-invasive diagnosis and treatment of some conditions. It will design new methods and strategies for drug discovery - enhancing R&D productivity in the pharmaceutical and agrochemical sectors and supporting faster, more cost-effective development of novel medicines for currently intractable diseases, or new herbicides. It will create high-value jobs, protect and attract inward investment, and drive long-term growth; and contribute to the delivery of the Government's innovation, industrial and regional strategies.The RFI will focus on high-risk, long-term R&D challenges. A high degree of uncertainty, significant spill-overs and the need for multi-party collaboration all contribute to under-investment by the private sector, relative to socially optimal levels. Government intervention - in the form of the RFI (£79.6m CDEL and £23.5m RDEL in the period 2016-21) - is needed to de-risk and accelerate early-stage discovery and innovation; and to foster the usability and integration (and therefore the real-world uptake) on which the disruptive impact of new technologies ultimately depends.

生命科学行业是英国经济的重要组成部分：它拥有超过22万名员工，对GDP和英国贸易平衡做出了重大贡献，对于为患者开发领先的治疗方法至关重要。它以英国在健康和生命科学方面世界领先的研究基地为基础。反过来，工程和物理科学（EPS）研究的进步使许多关键的研究突破成为可能，这些研究提供了越来越复杂的仪器和方法，以支持对活生物体（从微生物到植物、动物和人体）和生物过程（包括疾病病理学和药物作用）的研究。整个生态系统的研发——从基础认识到应用研究再到产品开发——对于实现长期经济增长和农业、食品安全、医疗保健和公共卫生领域的持续进步至关重要。历史上的创新模式往往是线性的，涉及一定程度的意外发现。如果物理科学家、工程师、生命科学家和工业界大规模合作，颠覆性技术和科学突破将会加速。这是罗莎琳德·富兰克林研究所（RFI）的领域：在哈维尔科学与创新校区设有一个中心（Hub），与英国领先的高等教育机构的正式辐条联系在一起，它将整合学术界和工业界的互补专业知识，创建一个国家卓越中心，用于物理和生命科学的融合方法开发。RFI将开发颠覆性的下一代成像技术，这将使我们对细胞和疾病生物学的理解发生变化，并对某些疾病进行非侵入性诊断和治疗。它将为药物发现设计新的方法和战略——提高制药和农用化学品部门的研发生产力，支持更快、更具成本效益地开发治疗目前难治性疾病的新药或新的除草剂。它将创造高价值的就业机会，保护和吸引外来投资，推动长期增长；并为政府的创新、工业和区域战略作出贡献。RFI将专注于高风险、长期的研发挑战。高度的不确定性、严重的溢出效应和多方合作的需要都导致私营部门投资不足，相对于社会最佳水平而言。政府干预——以RFI的形式（2016-21年期间为7960万英镑的CDEL和2350万英镑的RDEL）——需要降低风险并加速早期发现和创新；并促进可用性和集成（因此现实世界的吸收），这是新技术的破坏性影响最终依赖的。