Manufacturing Embedded Sensors within Microfluidic Reactors.

在微流体反应器中制造嵌入式传感器。

• 批准号: EP/R031266/1
• 负责人: Mark Platt
• 金额: $ 0.58万
• 依托单位: Loughborough University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FR031266%2F1
• 关键词: Manufacturing; Embedded; Sensors; within; Microfluidic

A traditional route to synthesising material was to mix the chemicals within a flask or beaker, these so called batch reactors are increasingly being replaced by flow reactors. Continuous flow reactors are proving powerful tools for synthesizing materials, they offer reduced production costs, a rapid method of optimising the reaction conditions, as well as reducing variation in products from batch-to-batch techniques. Infrequent sampling and monitoring of the products within fluidic reactors however removes any benefit of the flow process. For example if the products of a fluidic chip are analysed every day, and a failure occurs during this period, a days' worth of product are lost as the system is restarted. An infrequent sampling period equates flow chemistry to a batch-to-batch process with the quantity in each batch being the length of time between samples. Thus challenges in implementing micro reactor systems lie in the development of control and design strategies that guarantee uniform mixing, and fluidic behaviour and to facilitate the Inline monitoring of chemical products for high-throughput processing. Embedded sensor systems within bespoke reactors is an under researched field. New methods of manufacturing offer potential solutions, including the use of Additive Manufacturing (AM), or multistage builds using a variety of techniques such as lithography coupled with AM, would allow bespoke flow channels to be designed and optimised for the reaction and interface for the analytical platform. The research will develop the manufacturing process's for inline flow sensors. The benefits of these new sensors will then be applied to the production of nanomaterials and pharmaceuticals.

合成材料的传统方法是在烧瓶或烧杯中混合化学物质，这些所谓的间歇反应器正越来越多地被流动反应器所取代。事实证明，连续流动反应器是合成材料的强大工具，它们降低了生产成本，提供了一种快速优化反应条件的方法，并减少了分批技术中产品的差异。然而，对流体反应器内的产品进行不频繁的采样和监测，会消除流动过程的任何好处。例如，如果每天都要分析一个流控芯片的产品，而在此期间发生了故障，那么当系统重新启动时，就会损失相当于一天的产品。不频繁的采样周期将流动化学等同于一个批次到一个批次的过程，每个批次中的数量是样品之间的时间长度。因此，实施微型反应器系统的挑战在于制定控制和设计战略，以保证均匀的混合和流体行为，并促进对高通量加工的化学产品的在线监测。定制反应堆中的嵌入式传感器系统是一个研究较少的领域。新的制造方法提供了潜在的解决方案，包括使用添加制造(AM)，或使用各种技术(如光刻与AM结合)的多阶段构建，将允许针对分析平台的反应和界面设计和优化定制的流动通道。这项研究将开发在线流量传感器的制造工艺。然后，这些新传感器的好处将应用于纳米材料和药品的生产。