Application by the School of Chemistry and the School of Pharmacy, University of East Anglia, for enhanced single-crystal X-ray diffraction facilities

东安格利亚大学化学学院和药学院申请增强单晶X射线衍射设施

• 批准号: EP/S005854/1
• 负责人: Manfred Bochmann
• 金额: $ 78.5万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS005854%2F1
• 关键词: Application; Chemistry; Pharmacy; University; East

We are requesting resources under the Strategic Equipment Process for a dual-probe single-crystal X-ray diffraction system to underpin a broad range of research and development programmes in molecular sciences in Eastern England and to establish this facility as a regional centre. The determination of molecular structure by single-crystal X-ray diffraction is a key analytical technique, unrivalled in the information it provides about constitution, chemical bonding, stereochemistry, intra- and intermolecular interactions and phase changes of solid compounds. It is also often the cheapest form of precision analysis. This proposal seeks to take advantage of the technological step-changes in crystallography in the last 15 years to provide a new system capable of generating structural information on a wide range of compounds, from small molecule crystals to bio materials. This new facility will offer much improved capability, well beyond simply replacing the existing outdated equipment that has become economically unsustainable. It will be able to handle much smaller crystals and acquire data much faster, enabling us to broaden the user base and to tackle a much wider range of problems, including experiments we were not able to carry out before, such as the study of temperature-dependent phase changes in pharmaceutical materials. Given the geographical distribution of research centres in Eastern England, this instrumentation is of key strategic importance to UEA and will be operated as a generally accessible shared Norwich Research Park (NRP) facility. The University has agreed to provide long term management and maintenance support to ensure the continued successful operation beyond the lifetime of the grant.

我们正在根据战略设备程序申请资源，用于双探针单晶X射线衍射系统，以支持英格兰东部分子科学的广泛研究和开发方案，并将该设施建成区域中心。通过单晶X射线衍射测定分子结构是一项关键的分析技术，它提供了有关固体化合物的组成、化学键合、立体化学、分子内和分子间相互作用以及相变的无与伦比的信息。它通常也是最便宜的精度分析形式。该提案旨在利用过去15年来晶体学的技术进步，提供一种能够生成从小分子晶体到生物材料的各种化合物的结构信息的新系统。这一新设施将提供更高的能力，远远超出简单地更换现有的过时设备，这些设备在经济上已经不可持续。它将能够处理更小的晶体并更快地获取数据，使我们能够扩大用户群并解决更广泛的问题，包括我们以前无法进行的实验，例如药物材料中温度依赖性相变的研究。鉴于英格兰东部研究中心的地理分布，该仪器对东英吉利大学具有关键的战略重要性，并将作为一个普遍可访问的共享诺维奇研究园（NRP）设施运营。大学已同意提供长期的管理和维护支持，以确保在补助金有效期结束后继续成功运作。

项目成果

Copper(I) Complexes of P -Stereogenic Josiphos and Related Ligands

P-立构 Josiphos 的铜 (I) 配合物及相关配体

• DOI: 10.1002/ejoc.202100146
• 发表时间: 2021
• 期刊: European Journal of Organic Chemistry
• 影响因子: 2.8
• 作者: Arthurs R

Phosphorescent Carbene-Gold-Arylacetylide Materials as Emitters for Near UV-OLEDs.

磷光卡宾-金-芳基乙炔材料作为近紫外 OLED 的发射体。

• DOI: 10.1002/adma.202306249
• 发表时间: 2024
• 期刊: Advanced materials (Deerfield Beach, Fla.)
• 作者: Brannan AC

Electrochemically-Switched 2nd Order Non-Linear Optical Response in an Arylimido-Polyoxometalate with High Contrast and Cyclability.

• DOI: 10.1002/anie.202215537
• 发表时间: 2023-01-26
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Hood, Bethany R. R.;de Coene, Yovan;Torre Do Vale Froes, Afonso V. V.;Jones, Claire F. F.;Beaujean, Pierre;Liegeois, Vincent;MacMillan, Fraser;Champagne, Benoit;Clays, Koen;Fielden, John
• 通讯作者: Fielden, John

Application of a Ferrocene-Based Palladacycle Precatalyst to Enantioselective Aryl-Aryl Kumada Coupling

• DOI: 10.1002/ejic.202101077
• 发表时间: 2022-02-17
• 期刊: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
• 影响因子: 2.3
• 作者: Arthurs, Ross A.;Hughes, David L.;Richards, Christopher J.
• 通讯作者: Richards, Christopher J.

Electrochemically-Switched 2nd Order Non-Linear Optical Response in an Arylimido-Polyoxometalate with High Contrast and Cyclability

具有高对比度和可循环性的芳基酰亚胺多金属氧酸盐中的电化学切换二阶非线性光学响应

• DOI: 10.1002/ange.202215537
• 发表时间: 2022
• 期刊: Angewandte Chemie
• 作者: Hood B