Tissue-Responsive Robotic Implants for In Vivo Mechanostimulation-Based Tissue Regeneration (Tissue-RIMOTE)

用于体内基于机械刺激的组织再生的组织响应机器人植入物 (Tissue-RIMOTE)

• 批准号: EP/S021035/1
• 负责人: Dana Damian
• 金额: $ 26.57万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS021035%2F1
• 关键词: Tissue; Responsive; Robotic; Implants; Vivo

Conditions such as long-gap oesophageal atresia (LGOA) and short bowel syndrome (SBS) are two examples of chronic paediatric cases of gastrointestinal tissue reconstruction where up to two thirds of the oesophagus and bowel, respectively, may be missing. These are among the most complex and devastating paediatric anomalies that have a life-long debilitating effect on patients. Their current treatments are not widely available, are complex, primitive, long-term, and have disputed outcome quality. Families and surgeons have long sought an effective treatment to improve these patients' quality of life.The proposed project aims to initiate an ambitious research agenda for a novel technology for the repair and reconstruction of soft tubular tissues inside the body using robotic and tissue regeneration principles. The underlying technology unifies the fields of tissue engineering, surgery and medical implants into a new concept of 'robotic implants'. The proposed robotic implants are one-size-fits-all linings for tubular tissues that enable autonomous tissue-responsive mechanical interaction with tissues to induce their growth. Based on evidence from cell biology studies and clinical practice showing how tissues respond to mechanical stimulation in vivo, the proposed robotic implant applies gentle force directly to tissues to induce growth through cell proliferation. Thus, these robotic implants deliver controlled, long-term, customisable and optimal reconstructive therapy for tissues in an unprecedented way. The proposed technology has the potential to restore patients' mobility and social activity, as well as reduce hospitalisation and post-surgery complications, treatment and costs.This proposal has a pioneering focus: to develop the design, fabrication and control of robotic implants that can physically and physiologically adapt to the changing properties of tissues and stimulate their growth. These robotic implants will consist of fundamental, compact and functional elastomeric strands that can be assembled into an architecture that can elongate with the growing tissue and apply controlled, directional mechanical stimulation to the tissue.This project is the basis of an exciting interdisciplinary research framework that will allow communities of surgeons, biologists, tissue engineers and tissue mechanics researchers to investigate basic mechanisms of tissue growth and understand the relationships among tissue strain, tissue regeneration and inflammatory responses. In particular, the technology to be developed in this project will be a precursor clinical device for LGOA and SBS. This project also launches an investigation into soft robots that physically adapt and perform inside the body, which is imperative for tissue regeneration and growth as well as for wearable technologies that need to adapt to children's developmental stages.

长间隙食管闭锁（LGOA）和短肠综合征（SBS）等疾病是胃肠道组织重建的两个慢性儿科病例，其中可能分别缺失多达三分之二的食管和肠。这些是最复杂和最具破坏性的儿科异常，对患者有终身的衰弱影响。他们目前的治疗方法并不广泛，是复杂的，原始的，长期的，并有争议的结果质量。长期以来，家庭和外科医生一直在寻求有效的治疗方法来改善这些患者的生活质量。拟议的项目旨在启动一项雄心勃勃的研究议程，利用机器人和组织再生原理修复和重建体内软管状组织的新技术。基础技术将组织工程、外科手术和医疗植入物领域统一为“机器人植入物”的新概念。所提出的机器人植入物是用于管状组织的一种尺寸适合所有衬里，其能够与组织进行自主组织响应机械相互作用以诱导其生长。基于来自细胞生物学研究和临床实践的证据，显示组织如何对体内机械刺激做出反应，所提出的机器人植入物直接对组织施加温和的力，以通过细胞增殖诱导生长。因此，这些机器人植入物以前所未有的方式为组织提供受控，长期，可定制和最佳的重建治疗。这项技术有可能恢复患者的行动能力和社会活动能力，减少住院和术后并发症，减少治疗和成本。这项提议的开创性重点是：开发机器人植入物的设计、制造和控制，这些机器人植入物可以在物理和生理上适应组织的变化特性，并刺激它们的生长。这些机器人植入物将包括基本的，紧凑的和功能性的弹性股线，这些弹性股线可以组装成一个结构，该结构可以随着生长的组织伸长，并对组织施加受控的定向机械刺激。该项目是一个令人兴奋的跨学科研究框架的基础，该框架将使外科医生，生物学家，组织工程师和组织力学研究人员研究组织生长的基本机制，并了解组织应变，组织再生和炎症反应之间的关系。特别是，本项目中开发的技术将成为LGOA和SBS的前体临床器械。该项目还启动了对身体适应和在体内执行的软机器人的研究，这对于组织再生和生长以及需要适应儿童发育阶段的可穿戴技术至关重要。

项目成果

Flexible and Expandable Robot for Tissue Therapies – Modeling and Design

• DOI: 10.1109/tbme.2020.3007714
• 发表时间: 2020-07
• 期刊: IEEE Transactions on Biomedical Engineering
• 影响因子: 4.6
• 作者: Mohamed Atwya;C. Kavak;Elodie Alisse;YanQiang Liu;Dana D. Damian

Resistance Tuning of Soft Strain Sensor based on Ionic Liquid Concentration and Volume Changes

基于离子液体浓度和体积变化的软应变传感器电阻整定

• 发表时间: 2020
• 作者: Joanna J

Regenerative robotics.

再生机器人。

• DOI: 10.1002/bdr2.1533
• 发表时间: 2020
• 期刊: Birth defects research
• 影响因子: 2.1
• 作者: Damian DD

Wirelessly Magnetically Actuated Motor for Tissue Regeneration Robotic Implant

用于组织再生机器人植入的无线磁驱动电机

• DOI: 10.1109/iros47612.2022.9981834
• 发表时间: 2022
• 作者: Duffield C

Fault Tolerant Control in Shape-Changing In Vivo Robots

体内变形机器人的容错控制

• 发表时间: 2020
• 作者: Balasubramanian L