Comparative expression studies to identify cellular factors promoting Hendra virus replication for a comprehensive understanding of Hendra virus pathogenesis

比较表达研究，以确定促进亨德拉病毒复制的细胞因子，以全面了解亨德拉病毒发病机制

• 批准号: nhmrc : 1044228
• 负责人: Prof Hans Netter
• 金额: $ 24.98万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/comparative-expression-studies-virus-pathogenesis/111643
• 关键词: Comparative; expression; studies; identify; cellular

Hendra virus (HeV) is an emerging pathogen indigenous to fruit bats. HeV is associated with limited outbreaks with high mortality in domesticated animals and humans. To advance the understanding of HeV-related pathogenesis, we will perform comparative studies in bat and human cell lines to recognise differences in virus-host cell interactions leading to a comprehensive understanding of the HeV life cycle and pathogenesis.

亨德拉病毒（HeV）是果蝠本土的一种新兴病原体。 HeV 与家养动物和人类的有限爆发和高死亡率有关。为了加深对 HeV 相关发病机制的了解，我们将对蝙蝠和人类细胞系进行比较研究，以识别病毒与宿主细胞相互作用的差异，从而全面了解 HeV 生命周期和发病机制。