EPSRC Centre for Doctoral Training in Chemical Biology - Innovation for the Life Sciences

EPSRC 化学生物学博士培训中心 - 生命科学创新

• 批准号: EP/S023518/1
• 金额: $ 817.83万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Training Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS023518%2F1
• 关键词: EPSRC; Centre; Doctoral; Training; Chemical

Chemical biology research spearheads the development of novel molecular tools and technologies to study molecular interactions and address life sciences challenges. The impact of these technologies and understanding they unlock is transformative, supporting innovation across the UK economy, in sectors such as healthcare & med-tech, personal care, agri-science, and bio-tech; with a combined annual turnover > £100bn. It further supports the UK knowledge economy by kick-starting a new wave of disruptive SMEs. With the world population predicted to increase in both number and age, pressing demands are being made upon UK plc. This is leading to the industrialisation of the life sciences with Chemical Biology led molecular tools and technologies being dovetailed with "Industry 4.0" advances in additive manufacturing, machine learning and automation. Chemical Biology will therefore play a pivotal role in innovation R&D pipelines, enabling biological and biomedical research to advance more rapidly towards product development and end-user application, e.g. novel diagnostics and drugs to tackle disease; sensors and agro-chemicals/technologies for crop protection; improved formulations in the personal care sector; and increased understanding of nutrient impact on long-term health through advances in molecular measurement technologies. In parallel these advances will benefit the UK instrumentation science sector.There is a therefore a pressing need for a new type of PhD graduate able to embrace this industrial revolution of the life sciences, combining the creation of the next generation of molecular tools and technologies with industry 4.0 technologies. The Centre for Doctoral Training (CDT) in Chemical Biology: Innovation for the Life Sciences will directly address this skills shortage, by training ~80 PhD students, providing them with the skills to operate seamlessly across the physical/mathematical sciences and life sciences and capitalize upon and drive breakthroughs at the human-machine interface. Graduates will emerge armed with an in-depth understanding of product development pipelines acquired through first-hand experience of multi-disciplinary translational research and early stage commercialisation. This will enable them to become leaders of technology innovation in academia, industry and healthcare.To achieve this the CDT is working closely with industry and SMEs to develop new frameworks for training, collaboration and translation within a cohort-based programme, where no student is an island and diversity and equality are promoted at all levels. The PhD students will be supported by one of the largest Chemical Biology communities in the world, the Institute of Chemical Biology at Imperial College London, which brings together over >135 research groups and industry partners. They will also benefit from new innovation habitats designed to unlock student creativity, promote new lean and open innovation models, stimulating knowledge transfer and industry partner engagement, and kick-start their own companies.This training and research ecosystem will be a catalyst for new state of the art technology development, with each research project at the physical/mathematical and life sciences interface driving the development of new molecular technologies, addressing life science bottlenecks and transforming the path of the life sciences towards industry 4.0. The new bespoke innovative training programme will fuse exciting professional/transferable skills courses with world-class translational research, e.g. including a micro-MBA, science communication training at the BBC, industry placements, ideation and commercialisation competitions, hands-on prototyping, and will also provide a framework for responsible research with students being trained on ethical, societal, ecological and economical aspects of their projects. This will take place through a 1-year master course that seamlessly connects with a 3-year PhD research project.

化学生物学研究引领着新型分子工具和技术的发展，以研究分子相互作用并应对生命科学的挑战。这些技术的影响及其所带来的理解是变革性的，支持英国经济的创新，包括医疗保健和医疗技术、个人护理、农业科学和生物技术等领域;年营业额合计超过1000亿英镑。它通过启动新一波颠覆性中小企业来进一步支持英国知识经济。随着世界人口在数量和年龄上的增长，对英国公司提出了紧迫的要求。这导致了生命科学的工业化，化学生物学领导的分子工具和技术被“工业4.0”在增材制造，机器学习和自动化方面的进步所取代。因此，化学生物学将在创新研发管道中发挥关键作用，使生物和生物医学研究能够更快地向产品开发和最终用户应用发展，例如新的诊断方法和药物来应对疾病;传感器和农用化学品/作物保护技术;个人护理部门的改进配方;并通过分子测量技术的进步，提高对营养素对长期健康影响的认识。同时，这些进步将使英国仪器科学部门受益。因此，迫切需要一种新型的博士毕业生，能够拥抱生命科学的工业革命，将下一代分子工具和技术的创造与工业4.0技术相结合。化学生物学博士培训中心（CDT）：生命科学创新将通过培训约80名博士生直接解决这一技能短缺问题，为他们提供在物理/数学科学和生命科学中无缝操作的技能，并利用和推动人机界面的突破。毕业生将通过多学科转化研究和早期商业化的第一手经验，深入了解产品开发管道。这将使他们成为学术界、工业界和医疗保健领域技术创新的领导者。为了实现这一目标，CDT正在与工业界和中小企业密切合作，在一个基于群体的计划中开发新的培训、合作和翻译框架，在这个计划中，没有学生是一个孤岛，在各个层面促进多样性和平等。博士生将得到世界上最大的化学生物学社区之一的支持，伦敦帝国理工学院化学生物学研究所，汇集了超过135个研究小组和行业合作伙伴。他们还将受益于新的创新栖息地，旨在释放学生的创造力，促进新的精益和开放的创新模式，刺激知识转移和行业合作伙伴的参与，并启动自己的公司。这种培训和研究生态系统将成为最先进技术发展的催化剂，随着物理/数学和生命科学接口的每个研究项目推动新分子技术的发展，解决生命科学的瓶颈问题，改变生命科学走向工业4.0的道路。新的定制创新培训计划将融合令人兴奋的专业/可转移技能课程与世界一流的转化研究，例如，包括微型MBA，BBC的科学传播培训，行业实习，创意和商业化竞赛，动手原型，并将提供一个负责任的研究框架，学生将在项目的道德，社会，生态和经济方面接受培训。这将通过一个为期1年的硕士课程，与3年的博士研究项目无缝连接。