CHEMOPREVENTION OF CARCINOGENESIS BY NUCLEOPHILES

这项提议的目标是获得能够诱捕 胃肠道管腔内的直接致癌物 并防止它们攻击宿主组织。两个主要属性 对化合物的要求是作为捕捉剂和保留剂的有效性 在胃肠道内。后一种属性在 在整个消化道提供有效浓度 并有可能提供无毒的安全化合物。这个 该提案的具体目标如下：1.确定候选人 并提供这些化合物以供测试。2.确定……的能力 候选化合物与不同的直接作用基团反应 体外致癌物质，也与拉米夫五烯有关。3.确定留存 胃肠道内的测试化合物。4.确定 测试化合物捕获直接作用致癌物的能力 活体胃肠道的管腔。5.确定容量 抑制致癌物质诱发的肿瘤的测试化合物的数量 直接作用致癌物的管理。6.测定苯系物的毒性 有效的测试化合物。 该合作项目由一个行政单位和 两个机构的实验室。其中之一就是加州大学 明尼苏达州-检验医学和病理学系 化学专业。另一个是伊利诺伊理工学院。

The objective of this proposal is to obtain compounds that will trap direct-acting carcinogens within the lumen of the gastrointestinal tract and prevent them from attacking host tissues. Two major attributes required of the compounds are efficacy as trapping agents and retention within the gastrointestinal tract. This latter attribute is important in providing effective concentrations throughout the entire alimentary tract and potentially providing safe compounds in terms of lack of toxicity. The specific aims of the proposal are as follows: 1. To identify candidate compounds and provide these for testing. 2. To determine the capacity of the candidate compounds to react with a diverse group of direct-acting carcinogens in vitro and also with fecapentaene. 3. To determine retention of the test compounds within the gastrointestinal tract. 4. To determine the capacity of test compounds to trap direct-acting carcinogens within the lumen of the gastrointestinal tract in vivo. 5. To determine the capacity of test compounds to inhibit carcinogen-induced neoplasia resulting from administration of direct-acting carcinogens. 6. To determine toxicity of effective test compounds. THE COLLABORATIVE PROJECT consists of an administrative unit and laboratories at two institutions. One of these is the University of Minnesota - Department of Laboratory Medicine and Pathology and Department of Chemistry. The other is the Illinois Institute of Technology.