EFFICACY OF CHEMOPREVENTIVE AGENTS IN ANIMAL MODELS

将化学预防药物运送到目标部位的问题 未代谢的、高度集中的活动是一个区域 显然需要更多关注的研究。在 肺组织的情况下，一个明确的药物输送选择是 吸入含有化学防腐剂的气雾剂。最近 布地奈德的雾化给药已被证明 显著抑制苯并[a]磷所致小鼠肺腺瘤的形成 让一只小白鼠。 本工作说明的目标是研究 和疗效，探索预防肺癌的策略 化学防护剂的气雾剂输送。A/J小鼠肺脏 腺瘤模型应与高度普遍存在的B[a]P一起使用 在烟草烟雾中发现的环境致癌物质，但主要是由于 化石燃料的燃烧。正在接受测试的药物是布地奈德。 每只动物的肺腺瘤发生率被用作 这项研究的终点。此外，还有一系列中间体 终点包括细胞凋亡率、增殖细胞核抗原、微核率和倍性 变化正在被衡量。

The problem of delivering chemopreventive drugs to the target site of action in their unmetabolized, highly concentrated form is an area of research where clearly more attention needs to be focused. In the case of pulmonary tissue, one clear option for drug delivery is the inhalation of aerosols containing chemopreventive agents. Recently the aerosolized administration of budesonide has been shown to markedly inhibit B[a]P induced adenoma formation in lungs of the Strain A mouse. The objective of this workstatement is to investigate the mechanisms and efficacy and explore the strategy of preventing lung cancer by aerosol delivery of chemopreventive agents. The A/J mouse lung adenoma model shall be used with B[a]P, a highly ubiquitous environmental carcinogen found in tobacco smoke, but primarily due to the combustion of fossil fuels. The agent being tested is budesonide. The frequency of lung adenomas per animal is being used as the endpoint in this study. In addition a series of intermediate endpoints including apoptosis, PCNA, micronuclei frequency and ploidy changes are being measured.