Health assessment across biological length scales for personal pollution exposure and its mitigation (INHALE)

针对个人污染暴露及其缓解的跨生物长度尺度的健康评估（吸入）

• 批准号: EP/T003189/1
• 负责人: Christopher Pain
• 金额: $ 356万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FT003189%2F1
• 关键词: Health; assessment; across; biological; length

To assess the impact of pollution on personal health in outdoor/indoor urban environments, we will develop a physics-based multi-scale approach across biological length scales from the cell, lung, person (surrounded by green infrastructure) up to the neighbourhood scale. We will examine the biophysical components of pollutants that determine their cellular fate, their potential for cell and tissue damage and how this relates to health outcomes. We will use airway models to assess particle deposition and effects on people's health as well as trace the pollution particles through an individual person down to the cellular level. The focus of the analysis will be on the immediate micro-environment (~20m) around a person. The integrated modelling will also represent various intervention scenarios (e.g. roadside hedges or medication for at-risk people such as asthmatics) to assess reduced exposure and corresponding changes in health outcomes. These biologic parameters of exposure will be integrated with the cardio-respiratory response to pollution in 80 participants using a combination of cardio-respiratory, physical activity and personal fine particles exposure monitors. We will numerically model the pollution and air flows at the neighbourhood scale and apply an approach centred on the impact of pollution on health to all aspects of modelling, sensor placement and management of the environment. Thus, any mitigation strategies can be designed to minimize the impact of pollution on health.We will model the dispersion of particles and their micro-physics within the neighbourhood with an emphasis on green infrastructure and their ability to mitigate pollution e.g. hedges can reduce heavy metal pollution. We will examine the physical effects and functional chemistry of the metals and organic components of particles at the ultracellular level to determine their interference to cell metabolism and health. We will use modelling to predict the outcomes of cell fate, so that we can back propagate biological potential of pollution particles (say) through to the individual and into the neighbourhood scale. Thus, modelling will be key at each length scale.

为了评估室外/室内城市环境中污染对个人健康的影响，我们将开发一种基于物理学的多尺度方法，从细胞、肺、人（被绿色基础设施包围）到社区尺度。我们将研究污染物的生物物理成分，这些成分决定了它们的细胞命运，它们对细胞和组织损伤的潜力，以及这与健康结果的关系。我们将使用呼吸道模型来评估颗粒物沉积和对人们健康的影响，并通过个人追踪污染颗粒物到细胞水平。分析的重点将是一个人周围的直接微环境（约20米）。综合建模还将代表各种干预情景（例如路边树篱或哮喘患者等高危人群的药物），以评估减少的暴露和健康结果的相应变化。这些接触的生物参数将与80名参与者的心肺反应相结合，使用心肺，体力活动和个人细颗粒物接触监测器。我们将在邻里范围内对污染和空气流动进行数字建模，并将以污染对健康的影响为中心的方法应用于建模，传感器放置和环境管理的各个方面。因此，任何缓解策略都可以设计成最大限度地减少污染对健康的影响。我们将模拟颗粒物的分散及其在邻近地区的微观物理特性，重点是绿色基础设施及其缓解污染的能力，例如树篱可以减少重金属污染。我们将在超细胞水平上研究金属和颗粒有机成分的物理效应和功能化学，以确定它们对细胞代谢和健康的干扰。我们将使用建模来预测细胞命运的结果，这样我们就可以将污染颗粒的生物潜力反向传播到个人和邻居。因此，建模将是每个长度尺度的关键。

项目成果

Quantifying particulate matter reduction and their deposition on the leaves of green infrastructure

• DOI: 10.1016/j.envpol.2020.114884
• 发表时间: 2020-10-01
• 期刊: ENVIRONMENTAL POLLUTION
• 影响因子: 8.9
• 作者: Abhijith, K., V;Kumar, Prashant
• 通讯作者: Kumar, Prashant

Evaluation of respiratory deposition doses in the presence of green infrastructure

• DOI: 10.1007/s11869-021-00989-w
• 发表时间: 2021-02
• 期刊: Air Quality, Atmosphere & Health
• 作者: K. Abhijith;Prashant Kumar

SARS-CoV2 in public spaces in West London, UK during COVID-19 pandemic.

• DOI: 10.1136/bmjresp-2022-001574
• 发表时间: 2023-05
• 期刊: BMJ open respiratory research
• 影响因子: 4.1

Computational Science - ICCS 2021 - 21st International Conference, Krakow, Poland, June 16-18, 2021, Proceedings, Part V

计算科学 - ICCS 2021 - 第 21 届国际会议，波兰克拉科夫，2021 年 6 月 16-18 日，会议记录，第五部分

• DOI: 10.1007/978-3-030-77977-1_30
• 发表时间: 2021
• 作者: Amendola M

FN3K expression in COPD: a potential comorbidity factor for cardiovascular disease.

• DOI: 10.1136/bmjresp-2020-000714
• 发表时间: 2020-11
• 期刊: BMJ open respiratory research
• 影响因子: 4.1
• 作者: Alderawi A;Caramori G;Baker EH;Hitchings AW;Rahman I;Rossios C;Adcock I;Cassolari P;Papi A;Ortega VE;Curtis JL;Dunmore S;Kirkham P
• 通讯作者: Kirkham P