On-Demand Flexible Pharmacy Manufacturing in Extreme Environments

极端环境下的按需灵活制药制造

• 批准号: EP/T005475/1
• 负责人: Philip Williams
• 金额: $ 31万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FT005475%2F1
• 关键词: Demand; Flexible; Pharmacy; Manufacturing; Extreme

The world's space agencies have formed the Global Exploration Roadmap for the long-term human habitation of Mars. Achieving this goal requires adventurous manufacturing solutions across interdisciplinary boundaries of the engineering, physical and health sciences.When taken ill, it is a quick trip to the pharmacy...unless you are in space. For short space missions, it is feasible for an astronaut to carry general medicines to alleviate symptoms until they can return to Earth. 'Med Kits' for the Space Shuttle included small supplies of painkillers, antibiotics, antiemetics, etc. and the ISS has on board a reasonable assortment of medications, including IV and IM injectables, to cover an increased range of medical problems. A medical emergency and the necessary pharmaceutical intervention of an astronaut in Earth orbit can be accommodated by an aborted mission and early return. Such is not possible from planetary transit or from lunar or planetary habitation.What if small quantities of pharmaceuticals could be made onsite, in space and on demand; an "Astropharmacy"? Health systems in space need self-sufficiency - such as the ability to manufacture and test pharmaceuticals. They also need to be efficient, limiting waste and recycling materials where possible. Here, we propose to create and develop the innovative manufacturing capability of flexible on demand pharmaceutical production. Using the protein machinery of cells we will develop cell-free drug production in microfluidic system that can operate in the extreme conditions of space flight. We will incorporate novel in process quality control methods to ensure purity and functionality of the pharmaceutical. We propose the innovative use of paper to create a 'drug factory' which can be applied to the skin to delivery of the drug directly to the patient as it is made. Finally, we will demonstrate the concept of telepharmacy, where the design of a biopharmaceutical can be transmitted from one site and the drug manufactured at the remote site.

世界航天机构已经形成了人类长期居住火星的全球探索路线图。实现这一目标需要跨越工程、物理和健康科学的跨学科边界的冒险制造解决方案。生病时，只需快速前往药房。除非你在太空中。对于短期太空任务，宇航员可以携带一般药物来缓解症状，直到他们可以返回地球。航天飞机的“医疗包”包括少量止痛药、抗生素、止吐药等，国际空间站上有各种合理的药物，包括IV和IM注射剂，以解决越来越多的医疗问题。中止使命和提前返回可解决地球轨道上的宇航员的医疗紧急情况和必要的药物干预。这是不可能从行星过境或从月球或行星居住。如果少量的药物可以在现场，在太空和按需制造;一个“太空药房”？太空中的卫生系统需要自给自足-例如制造和测试药品的能力。它们还需要高效，尽可能限制废物和回收材料。在这里，我们建议创建和开发灵活的按需制药生产的创新制造能力。利用细胞的蛋白质机制，我们将在微流控系统中开发无细胞药物生产，该系统可以在太空飞行的极端条件下运行。我们将采用新的过程质量控制方法，以确保药物的纯度和功能。我们建议创新使用纸张来创建一个“药物工厂”，可以应用于皮肤，直接将药物输送给患者。最后，我们将展示远程制药的概念，其中生物制药的设计可以从一个站点传输，而药物在远程站点制造。

项目成果

In-Space Manufacturing and Resources - Earth and Planetary Exploration Applications

太空制造和资源 - 地球和行星探索应用

• DOI: 10.1002/9783527830909.ch2
• 发表时间: 2022
• 作者: Williams P