Complex epistasis between JNK and PI3K pathway mutations in breast cancer.

乳腺癌中 JNK 和 PI3K 通路突变之间的复杂上位性。

• 批准号: nhmrc : GNT1158844
• 金额: $ 68.67万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/complex-epistasis-jnk-breast-cancer/1379051
• 关键词: Complex; epistasis; between; JNK; PI3K

Patients with luminal B breast cancer do not benefit from hormonal therapy, and will typically require treatment with chemotherapy. However, the majority of these patients will not respond to this treatment, although there are no reliable predictive markers of response. Here we will characterise the function and prognostic significance of a number of common breast cancer mutations in order to develop such a patient specific predictive marker.

B腔乳腺癌患者不能从激素治疗中获益，通常需要化疗。然而，大多数患者对这种治疗没有反应，尽管没有可靠的反应预测标记。在这里，我们将描述一些常见的乳腺癌突变的功能和预后意义，以便开发这样一个患者特异性的预测标志物。