Complex epistasis between JNK and PI3K pathway mutations in breast cancer.
Complex epistasis between JNK and PI3K pathway mutations in breast cancer.
乳腺癌中 JNK 和 PI3K 通路突变之间的复杂上位性。
批准号：
nhmrc : GNT1158844
负责人：
金额：
$68.67万
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2019
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2019-01-01 至 --
中文摘要
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英文摘要
Patients with luminal B breast cancer do not benefit from hormonal therapy, and will typically require treatment with chemotherapy. However, the majority of these patients will not respond to this treatment, although there are no reliable predictive markers of response. Here we will characterise the function and prognostic significance of a number of common breast cancer mutations in order to develop such a patient specific predictive marker.
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