MONITORING HUMAN EXPOSURE TO AFLATOXINS IN THE GAMBIA
MONITORING HUMAN EXPOSURE TO AFLATOXINS IN THE GAMBIA
批准号:
3549178
负责人:
John D Groopman
金额:
$20.98万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-09-15 至 1992-07-31
关键词:
DNA affinity chromatography aflatoxins chemical addition diet environmental toxicology epidemiology food contamination high performance liquid chromatography human milk human subject liver neoplasms nutrition related neoplasm /cancer nutrition related tag radioimmunoassay serum albumin toxin metabolism urinalysis
中文摘要
黄曲霉毒素(AFBl)是肝脏中最有效的毒素之一
英文摘要
Aflatoxin Bl (AFBl) is one of the most potent liver
carcinogens known for experimental animals. This chemical is also
present in the environment as a result of mold related
spoilage of foods and commodities. Consumption of these foods
results in high intake of AFBl by people living in many regions
of Asia and Africa. A number of researchers have used classic
epidemiological methods to examine the possible causal relationship
between AFBl in the diet and liver cancer. While strong
associations between AFBl exposure and liver cancer have been
found, new technologies have only recently become available
to monitor individual exposure and metabolism of aflatoxin Bl in
people. These methods will facilitate the dissection of the role
of viral agents, such as hepatitis B, from aflatoxins in the
etiology of liver cancer. The development of biomarkers to
assess the exposure to aflatoxin will help in efforts to limit the
potential risk in human populations. In the following proposed
study we will examine both seasonal and annual variabilities in
aflatoxin intake, metabolism, urinary and albumin disposition in
people living in the Gambia, West Africa who are at high risk to
develop liver cancer.
These studies will systematically probe the correspondence between
dietary intake of aflatoxins with biological markers, such as
excreted AFB-DNA adducts, oxidative metabolites in urine, aflatoxin
Ml in human milk and covalently bound aflatoxin to serum albumin,
to determine which of these markers have utility for non-invasively
assessing the exposure status of people at high risk for liver
cancer.
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Detoxication of Air Pollutants in Humans with a Broccoli Supplement
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批准号:8885232
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项目类别:
-
资助金额:$43.74万
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财政年份:2015
-
负责人:John D Groopman
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依托单位:
RESEARCH PROJECT 1: Chemical and Viral Biomarkers of Exposure and Risk (Groopman)
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批准号:8376299
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项目类别:
-
资助金额:$40.77万
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财政年份:2012
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负责人:John D Groopman
-
依托单位:
CORE B: Administrative Core
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批准号:8278593
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项目类别:
-
资助金额:$11.74万
-
财政年份:2011
-
负责人:John D Groopman
-
依托单位:
RESEARCH PROJECT 1: Chemical and Viral Biomarkers of Exposure and Risk (Groopman)
-
批准号:8278588
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项目类别:
-
资助金额:$48.62万
-
财政年份:2011
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负责人:John D Groopman
-
依托单位:
CORE B: Administrative Core
-
批准号:8078955
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项目类别:
-
资助金额:$11.98万
-
财政年份:2010
-
负责人:John D Groopman
-
依托单位:
Core C
-
批准号:7407113
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项目类别:
-
资助金额:$10.58万
-
财政年份:2008
-
负责人:John D Groopman
-
依托单位:
Core B
-
批准号:7407107
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项目类别:
-
资助金额:$17.15万
-
财政年份:2008
-
负责人:John D Groopman
-
依托单位:
Serum Biomarkers of Hepatic Response to Cancer Chemopreventive Intervention
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批准号:7545518
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项目类别:
-
资助金额:$17.84万
-
财政年份:2008
-
负责人:John D Groopman
-
依托单位:
CORE B: Administrative Core
-
批准号:7515940
-
项目类别:
-
资助金额:$11.41万
-
财政年份:2008
-
负责人:John D Groopman
-
依托单位:
Integrative Health Sciences
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批准号:7434800
-
项目类别:
-
资助金额:$68.03万
-
财政年份:2008
-
负责人:John D Groopman
-
依托单位:
Serum Biomarkers of Hepatic Response to Cancer Chemopreventive Intervention
-
批准号:7385183
-
项目类别:
-
资助金额:$21.4万
-
财政年份:2008
-
负责人:John D Groopman
-
依托单位:
Administrative Core
-
批准号:7434801
-
项目类别:
-
资助金额:$37.12万
-
财政年份:2008
-
负责人:John D Groopman
-
依托单位:
RESEARCH PROJECT 1: Chemical and Viral Biomarkers of Exposure and Risk (Groopman)
-
批准号:7515836
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项目类别:
-
资助金额:$40.9万
-
财政年份:2008
-
负责人:John D Groopman
-
依托单位:
CORE--PILOT PROJECTS
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批准号:7393271
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项目类别:
-
资助金额:$29.73万
-
财政年份:2007
-
负责人:John D Groopman
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依托单位:
MOLECULAR BIOMARKERS FOR HUMAN LIVER CANCER
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批准号:6467576
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项目类别:
-
资助金额:$19.33万
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财政年份:2001
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负责人:John D Groopman
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依托单位:
MOLECULAR BIOMARKERS FOR HUMAN LIVER CANCER
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批准号:6320844
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项目类别:
-
资助金额:$30.2万
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财政年份:2000
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负责人:John D Groopman
-
依托单位:
MOLECULAR BIOMARKERS FOR HUMAN LIVER CANCER
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批准号:6106353
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项目类别:
-
资助金额:$30.2万
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财政年份:1999
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负责人:John D Groopman
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依托单位:
MOLECULAR BIOMARKERS FOR HUMAN LIVER CANCER
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批准号:6271224
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项目类别:
-
资助金额:$32.56万
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财政年份:1998
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负责人:John D Groopman
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依托单位:
MOLECULAR BIOMARKERS FOR HUMAN LIVER CANCER
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批准号:6239643
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项目类别:
-
资助金额:$29.59万
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财政年份:1997
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负责人:John D Groopman
-
依托单位:
MOLECULAR BIOMARKERS FOR ENVIRONMENTAL TOXICANTS
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批准号:7849777
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项目类别:
-
资助金额:$187.32万
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财政年份:1997
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负责人:John D Groopman
-
依托单位:
海外基金