DO FISH OILS PREVENT RESTENOSIS POST-CORONARY ANGIOPLAST

鱼油可以预防冠状动脉血管成形术后再狭窄吗

• 批准号: 3553274
• 负责人: ALEXANDER LEAF
• 金额: $ 135.21万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553274
• 关键词: antiatherogenic agent; aspirin; atherosclerosis; coronary occlusion /thrombosis; dietary supplements; fibrinolytic therapy; heart circulation; human subject; human therapy evaluation; intraluminal angioplasty; marine animal oil; omega 3 fatty acid; platelet aggregation inhibitors; relapse /recurrence; therapy compliance; unsaturated fatty acids

The object of this collaborative study is to determine whether a dietary supplement of n-3 polyunsaturated fatty acids (PUFA) will decrease the restenosis rate percutaneous transluminal coronary angioplasty (PTCA). This procedure has proven very useful in relieving the symptoms and improving myocardial perfusion in coronary artery disease; however, its "Achilles heel" is the 25 to 35 percent restenosis rate that occurs within 6 to 8 months post PTCA. Reduction in restenosis rates will be tested in a double-blind, randomized, placebo-controlled, prospective study in patients undergoing angioplasty of native coronary arteries. All subjects will receive usual clinical therapy including 324 mg of aspirin per day and will be instructed in the American Heart Association phase I diet; half will receive n-3 PUFA (the intervention group) and the other half will receive a similar amount of vegetable oil (the placebo group). Adherence to diet and capsules will be maintained and monitored by monthly interview and analyses of plasma and red blood cell phospholipid content of n-3 fatty acids as well as capsule count. If a beneficial effect on the restenosis rate is achieved - and we are seeking a 33% reduction in the n-3 intervention group - it will have a very important impact on the management of the many patients undergoing PTCA. Since after the first few weeks, during which thrombi cause the failures, the restenosis process is pathologically an accelerated atherosclerosis, we expect the results to have broader implications for the prevention of atherosclerosis and coronary artery disease, the major cause of death in the U.S. and in Western industrialized countries. There is much confusion in the minds of both the public and physicians regarding possible beneficial health effects of fish oil. This study is undertaken to establish factual information on which to judge this issue.

这项合作研究的目的是确定饮食是否 补充n-3多不饱和脂肪酸（PUFA）会降低 再狭窄率经皮腔内冠状动脉成形术（PTCA）。 这个过程已被证明是非常有用的，在缓解症状， 改善冠状动脉疾病的心肌灌注;然而， “阿喀琉斯之踵”是25%到35%的再狭窄率， 在PTCA术后6 - 8个月。 再狭窄率的降低将 在一项双盲、随机、安慰剂对照、前瞻性 在接受自体冠状动脉血管成形术的患者中进行的研究。 所有受试者将接受常规临床治疗，包括324 mg的 每天服用阿司匹林，并将在美国心脏协会接受指导 第一阶段饮食;一半将接受n-3 PUFA（干预组）， 另一半将接受类似数量的植物油（安慰剂 组）。 将维持并监测对饮食和胶囊的依从性 通过每月的访问和血浆和红细胞分析， n-3脂肪酸的磷脂含量以及胶囊计数。 如果 实现了对再狭窄率的有益影响-我们正在寻求 在n-3干预组中减少33%-它将有一个非常 对许多接受PTCA的患者的管理产生重要影响。 因为在最初的几周后，血栓会导致失败， 再狭窄过程在病理上是加速的动脉粥样硬化， 我们希望这些结果对预防 动脉粥样硬化和冠状动脉疾病，死亡的主要原因， 美国和西方工业化国家。 在公众和医生的头脑中有很多困惑 关于鱼油可能对健康有益的问题。 本研究 我们承诺建立事实资料，据以判断这一问题。