DO FISH OILS PREVENT RESTENOSIS POST-CORONARY ANGIOPLAST

这项合作研究的目的是确定一种饮食是否 补充n-3多不饱和脂肪酸将降低 再狭窄率经皮冠状动脉腔内成形术(PTCA)。 这一过程已被证明在缓解症状和 改善冠状动脉疾病的心肌灌注；然而，其 “阿喀琉斯之踵”是指25%到35%的再狭窄率。 PTCA术后6至8个月内。降低再狭窄率将是 在双盲、随机、安慰剂对照、前瞻性试验中测试 自体冠状动脉血管成形术患者的研究。 所有受试者都将接受常规临床治疗，包括324毫克 每天服用阿司匹林，并将在美国心脏协会接受指导 第一阶段饮食；一半将接受n-3多不饱和脂肪酸(干预组)和 另一半将获得等量的植物油(安慰剂 组)。将保持和监测对饮食和胶囊的坚持 通过每月访谈和对血浆和红细胞的分析 N-3脂肪酸的磷脂含量以及胶囊数。如果一个 对再狭窄率产生了有益的影响--我们正在寻求 在n-3干预组中减少33%-它将有非常 对众多PTCA患者的管理产生重要影响。 因为在血栓导致失败的最初几周之后， 再狭窄的过程在病理上是加速的动脉粥样硬化， 我们预计结果将对预防艾滋病产生更广泛的影响。 动脉粥样硬化和冠状动脉疾病是中国人死亡的主要原因 美国和西方工业化国家。 公众和医生的头脑中都有许多困惑 关于鱼油可能对健康有益的影响。这项研究是 承诺建立判断这一问题的事实信息。

The object of this collaborative study is to determine whether a dietary supplement of n-3 polyunsaturated fatty acids (PUFA) will decrease the restenosis rate percutaneous transluminal coronary angioplasty (PTCA). This procedure has proven very useful in relieving the symptoms and improving myocardial perfusion in coronary artery disease; however, its "Achilles heel" is the 25 to 35 percent restenosis rate that occurs within 6 to 8 months post PTCA. Reduction in restenosis rates will be tested in a double-blind, randomized, placebo-controlled, prospective study in patients undergoing angioplasty of native coronary arteries. All subjects will receive usual clinical therapy including 324 mg of aspirin per day and will be instructed in the American Heart Association phase I diet; half will receive n-3 PUFA (the intervention group) and the other half will receive a similar amount of vegetable oil (the placebo group). Adherence to diet and capsules will be maintained and monitored by monthly interview and analyses of plasma and red blood cell phospholipid content of n-3 fatty acids as well as capsule count. If a beneficial effect on the restenosis rate is achieved - and we are seeking a 33% reduction in the n-3 intervention group - it will have a very important impact on the management of the many patients undergoing PTCA. Since after the first few weeks, during which thrombi cause the failures, the restenosis process is pathologically an accelerated atherosclerosis, we expect the results to have broader implications for the prevention of atherosclerosis and coronary artery disease, the major cause of death in the U.S. and in Western industrialized countries. There is much confusion in the minds of both the public and physicians regarding possible beneficial health effects of fish oil. This study is undertaken to establish factual information on which to judge this issue.