A comprehensive genomic analysis of oesophageal adenocarcinoma: understanding the genetic aetiology of OAC towards biomarkers of progression, prognosis and targeted treatment.

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Oesophageal cancer (OAC) continues to have poor survival despite surgery, chemotherapy and radiotherapy. Selecting patients for the most appropriate therapies and improving survival remain unmet research needs. We propose to undertake a detailed genetic study of OAC, including “next generation” sequencing, in order to catalogue the genetic changes in the disease. This information forms an essential basis for identifying genetic signatures of OAC progression, prognosis and treatment response.