A comprehensive genomic analysis of oesophageal adenocarcinoma: understanding the genetic aetiology of OAC towards biomarkers of progression, prognosis and targeted treatment.

食管腺癌的全面基因组分析：了解 OAC 的遗传病因学，了解进展、预后和靶向治疗的生物标志物。

• 批准号: nhmrc : 1021403
• 负责人: A/Pr Lutz Krause
• 金额: $ 65.87万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/comprehensive-genomic-analysis-targeted-treatment/110118
• 关键词: comprehensive; genomic; analysis; oesophageal; adenocarcinoma

Oesophageal cancer (OAC) continues to have poor survival despite surgery, chemotherapy and radiotherapy. Selecting patients for the most appropriate therapies and improving survival remain unmet research needs. We propose to undertake a detailed genetic study of OAC, including “next generation” sequencing, in order to catalogue the genetic changes in the disease. This information forms an essential basis for identifying genetic signatures of OAC progression, prognosis and treatment response.

食管癌（OAC）尽管进行了手术、化疗和放疗，但生存率仍然很低。选择患者进行最合适的治疗和提高生存率仍然是未满足的研究需求。我们建议对OAC进行详细的遗传研究，包括“下一代”测序，以便对疾病的遗传变化进行编目。这些信息构成了识别OAC进展、预后和治疗反应的遗传特征的重要基础。