TRIALS OF HYPERTENSION PREVENTION

这项拟议的研究是一项合作研究，涉及两个 密西西比大学的组成部分。我们建议 招募225名临界高血压患者(DBP 85-95 mm Hg)中度超重(理想体重的120%-150%)。 然后，他们将参加以下饮食改变 计划：1)减肥，2)减肥加增加 钙，3)减肥加上增加锻炼，以及4)体重 损失加上增加的钾(最后一种情况只在 杰克逊网站)。将要进行减肥的参与者 和锻炼计划将有确定的健康 (跑步机)在基线和随访时进行。初级阶段 这一阶段研究的目的是确定以下能力 改变中间变量。然而，血液中的差异 对照组和每个饮食组之间的压力下降 并且其他变化变量应该能够被确定， 尽管饮食组之间在血液中的明显差异 不太可能看到压力。对红细胞流量的研究将 检查这些指标是否与饮食反应有关 变化。

This proposed study is a cooperative one involving two components of the University of Mississippi. We propose to enroll 225 borderline hypertensive individuals (DBP 85-95 mm Hg) who are moderately overweight (120-150% of ideal weight). They will then be enrolled in the following dietary change programs: 1) weight loss, 2) weight loss plus increased calcium, 3) weight loss plus increased exercise, and 4) weight loss plus increased potassium (the last condition only at the Jackson site). Participants who are to undergo the weight loss and exercise protocol will have determination of fitness (treadmill) made at baseline and at follow-up. The primary purpose of this phase of the study is to determine ability to change intervening variables. However, differences in blood pressure fall between the control group and each of the dietary and other change variables should be able to be determined, although clear differences between the dietary groups in blood pressure is unlikely to be seen. Studies of red cell flux will be done to see if these correlate with response to dietary change.