TRIALS OF HYPERTENSION PREVENTION

这项拟议的研究是一项合作研究，涉及两个 密西西比大学的组成部分。 我们建议 入选225例临界高血压患者（DBP 85-95 mm 中度超重（理想体重的120-150%）。 然后，他们将参加以下饮食变化 程序：1）减肥，2）减肥加增加 钙，3）减肥加增加运动，以及4）体重 损失加上钾增加（最后一个条件仅在 杰克逊网站）。 将接受减肥的受试者 锻炼方案将确定健康状况 （跑步机）在基线和随访时进行。 主 本阶段研究的目的是确定 改变中间变量。 然而，血液的差异 对照组和每个饮食组之间的压力下降 并且应当能够确定其他变化变量， 尽管不同饮食组的血液中 压力不太可能被看到。 红细胞流量的研究将 看看这些是否与饮食反应相关， 变化

This proposed study is a cooperative one involving two components of the University of Mississippi. We propose to enroll 225 borderline hypertensive individuals (DBP 85-95 mm Hg) who are moderately overweight (120-150% of ideal weight). They will then be enrolled in the following dietary change programs: 1) weight loss, 2) weight loss plus increased calcium, 3) weight loss plus increased exercise, and 4) weight loss plus increased potassium (the last condition only at the Jackson site). Participants who are to undergo the weight loss and exercise protocol will have determination of fitness (treadmill) made at baseline and at follow-up. The primary purpose of this phase of the study is to determine ability to change intervening variables. However, differences in blood pressure fall between the control group and each of the dietary and other change variables should be able to be determined, although clear differences between the dietary groups in blood pressure is unlikely to be seen. Studies of red cell flux will be done to see if these correlate with response to dietary change.