MACULAR PHOTOCOAGULATION STUDY

黄斑光凝研究

• 批准号: 3551579
• 负责人: GARY FISH
• 金额: $ 3.49万
• 依托单位: TEXAS RETINA ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3551579
• 关键词: aging; disease /disorder prevention /control; eye laser surgery; eye surgery; human subject; human therapy evaluation; patient /disease registry; photocoagulation therapy; retina degeneration; vision tests

The proposed Foveal Photocoagulation Study is a multicenter study of treatment for age-related macular degeneration (AMD) in eyes with subfoveal neovascular lesions. The study consists of two randomized controlled trials of laser photocoagulation treatment and a natural history study of eyes ineligible for the trials. Eligible AMD patients who meet the visual acuity criteria for the randomized trials (20/80 vA 20/320) will be assigned to treatment or to no treatment of the neovascular lesion. Nature history study patients will have AMD and a subfoveal neovascular lesion but visual acuity better than 20/80. The purpose of the randomized trials is to determine whether krypton red laser photocoagulation is effective in preventing or delaying severe loss of vision in AMD patients who have subfoveal lesions, whether there are new neovascular lesions or recurrent neovascularization subfoveally following prior treatment for extrafoveal or juxtafoveal lesions. The purpose of the natural history study is to determine the rate at which visual acuity deteriorate to 20/80 or worse in eyes with AMD and subfoveal neovascular membranes after initial clinical presentation of patients who would otherwise be eligible for the randomized trials. The study will be carried out in twelve Clinical Centers, a Coordinating Center, and a Fundus Photograph Reading Center; the study investigators and centers consist primarily of those who have collaborated in the Macular Photocoagulation Study (MPS) over the past six years.

拟议的中心凹光凝研究是一项多中心研究 治疗黄斑中心凹下的年龄相关性黄斑变性（AMD） 新生血管病变。 该研究包括两项随机对照研究 激光光凝治疗的试验和自然史研究 眼睛不适合参加试验。 符合视力的AMD患者 随机试验的敏锐度标准 (20/80 vA 20/320) 将是 分配对新生血管病变进行治疗或不进行治疗。 自然 历史研究患者将患有 AMD 和中心凹下新生血管病变，但 视力优于20/80。 随机试验的目的是确定氪红是否 激光光凝可有效预防或延缓严重损失 患有黄斑中心凹病变的 AMD 患者的视力情况，是否有新的 新生血管病变或中心凹下复发性新生血管形成 先前治疗过中心凹外或中心凹旁病变。 目的 自然历史研究的目的是确定视力变化的速度 患有 AMD 和中心凹下新生血管的眼睛恶化至 20/80 或更糟 患者初次临床表现后的膜 否则有资格参加随机试验。 该研究将在十二个临床中心（一个协调中心）进行 中心和眼底照片阅读中心；研究人员和 中心主要由在黄斑部合作过的人员组成 过去六年的光凝研究（MPS）。