NIMH-CLINICAL RESEARCH BRANCH PSYCHOBIOLOGY OF DEPRESSIO

这项六中心合作研究的主要目的是测试 这些假设涉及神经生物学机制， 情感障碍的病因和维持。 这 开发了协作方法，以提供 具有不同学科专门知识的调查人员联合会 设计和进行研究。 该研究使用统一的 诊断标准和行为方法，以评估 在相同的主题中多个生物系统的功能。 它规定在基线无药期进行评估， 经过四周的抗抑郁药物治疗后 这 协作努力使早期和当前的测试成为可能 假设，并检查生物之间的相互作用 制度和行为。 所有数据分析和假设检验的初始阶段都有 基本上已经完成。 这份补助金申请代表了一个 请求最后一个支助期，在此期间， 涉及两个或两个以上生物学假设的检验 系统和行为，将得出结论。

The major aim of this six-center collaborative study was to test hypotheses which implicate neurobiological mechanisms in the etiology and maintenance of the affective disorders. This collaborative approach was developed in order to provide a consortium of investigators having expertise in diverse disciplines to design and conduct the research. The study utilized uniform diagnostic criteria and behavioral methods, so as to assess the functioning of multiple biological systems in the same subjects. It provided for assessment during a baseline drug-free period and after four weeks of antidepressant drug treatment. This collaborative effort makes it possible to test earlier and current hypotheses, and to examine interactions across and among biological systems and behavior. All data analysis and the initial phase of hypothesis testing have been essentially completed. This grant application represents a request for a final period of support during which the second phase of the testing of hypotheses which involve two or more biological systems and behavior, will be brought to a conclusion.