NIMH-CLINICAL RESEARCH BRANCH PSYCHOBIOLOGY DEPRESSION

NIMH 临床研究分支心理生物学抑郁症

• 批准号: 3553865
• 负责人: JAMES W MAAS
• 金额: $ 12.06万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553865
• 关键词: antidepressants; behavior test; bipolar depression depressed phase; bipolar depression manic phase; cooperative study; disease /disorder classification; human therapy evaluation; mental disorder chemotherapy; mental disorder diagnosis; neuroendocrine system; neurotransmitter metabolism; psychobiology; psychopharmacology

The major aim of this six-center collaborative study was to test hypotheses which implicate neurobiological mechanisms in the etiology and maintenance of the affective disorders. This collaborative approach was developed in order to provide a consortium of investigators having expertise in diverse disciplines to design and conduct the research. The study utilized uniform diagnostic criteria and behavioral methods, so as to assess the functioning of multiple biological systems in the same subjects. It provided for assessment during a baseline drug-free period and after four weeks of antidepressant drug treatment. This collaborative effort makes it possible to test earlier and current hypotheses, and to examine interactions across and among biological systems and behavior. All data analysis and the initial phase of hypothesis testing have been essentially completed. This grant application represents a request for a final period of support during which the second phase of the testing of hypotheses which involve two or more biological systems and behavior, will be brought to a conclusion.

这项六中心合作研究的主要目的是测试 这些假设涉及神经生物学机制， 情感障碍的病因和维持。 这 开发了协作方法，以提供 具有不同学科专门知识的调查人员联合会 设计和进行研究。 该研究使用统一的 诊断标准和行为方法，以评估 在相同的主题中多个生物系统的功能。 它规定在基线无药期进行评估， 经过四周的抗抑郁药物治疗后 这 协作努力使早期和当前的测试成为可能 假设，并检查生物之间的相互作用 制度和行为。 所有数据分析和假设检验的初始阶段都有 基本上已经完成。 这份补助金申请代表了一个 请求最后一个支助期，在此期间， 涉及两个或两个以上生物学假设的检验 系统和行为，将得出结论。

项目成果

Specificity of mixed affective states: clinical comparison of dysphoric mania and agitated depression.

混合情感状态的特异性：烦躁躁狂和激越抑郁的临床比较。

• DOI: 10.1016/0165-0327(93)90036-j
• 发表时间: 1993
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Swann,AC;Secunda,SK;Katz,MM;Croughan,J;Bowden,CL;Koslow,SH;Berman,N;Stokes,PE
• 通讯作者: Stokes,PE

Depressive mania versus agitated depression: biogenic amine and hypothalamic-pituitary-adrenocortical function.

抑郁性躁狂与激越性抑郁：生物胺和下丘脑-垂体-肾上腺皮质功能。

• DOI: 10.1016/0006-3223(94)91143-6
• 发表时间: 1994
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Swann,AC;Stokes,PE;Secunda,SK;Maas,JW;Bowden,CL;Berman,N;Koslow,SH
• 通讯作者: Koslow,SH

Hypothalamic-pituitary-adrenocortical function in mixed and pure mania.

混合型和纯粹型躁狂症中的下丘脑-垂体-肾上腺皮质功能。

• DOI: 10.1111/j.1600-0447.1992.tb01468.x
• 发表时间: 1992
• 期刊: Acta psychiatrica Scandinavica
• 影响因子: 6.7
• 作者: Swann,AC;Stokes,PE;Casper,R;Secunda,SK;Bowden,CL;Berman,N;Katz,MM;Robins,E
• 通讯作者: Robins,E

Psychomotor performance and monoamine function in bipolar and unipolar affective disorders.

双相和单相情感障碍的精神运动表现和单胺功能。

• DOI: 10.1016/s0006-3223(98)00172-3
• 发表时间: 1999
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Swann,AC;Katz,MM;Bowden,CL;Berman,NG;Stokes,PE
• 通讯作者: Stokes,PE

Response to treatment with antidepressants of patients with severe or moderate nonpsychotic depression and of patients with psychotic depression.

重度或中度非精神病性抑郁症患者和精神病性抑郁症患者对抗抑郁药治疗的反应。

• DOI: 10.1176/ajp.147.5.621
• 发表时间: 1990
• 期刊: The American journal of psychiatry
• 作者: Kocsis,JH;Croughan,JL;Katz,MM;Butler,TP;Secunda,S;Bowden,CL;Davis,JM
• 通讯作者: Davis,JM