PULMONARY COMPLICATIONS OF HIV INFECTION

HIV 感染的肺部并发症

• 批准号: 3553529
• 负责人: PAUL A KVALE
• 金额: $ 7.6万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1994-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553529
• 关键词: HIV infections; Pneumocystis pneumonia; acute bronchitis; bacterial pneumonia; blood cell count; ethnic group; female; gender difference; helper T lymphocyte; human subject; immunologic skin test; longitudinal human study; male; opportunistic infections; questionnaires; racial /ethnic difference; respiratory disorder epidemiology; respiratory function; respiratory imaging /visualization; statistics /biometry; tuberculin test; tuberculosis

This submission is one of six from the multicenter Pulmonary AIDS Complications Study (PACS) project. Our primary aim is to continue a study providing data on the frequency and types of lung diseases that occur in persons with HIV infection and to describe the course and outcome of these disorders. Particular attention will be given to identifying patterns of complications among demographic subgroups that have not been extensively studied such as women and blacks, and to defining differences between HIV transmission groups. The unique cohort that has been established by PACS will also provide an opportunity for new insights into particular complications such as airways disease and tuberculosis, allow the testing of novel approaches to the diagnosis of tuberculous infection and the prediction of pulmonary complications, and allow a better definition of the impact of early pulmonary events on the later stages of HIV infection and its complications. This information is essential to the development of clinical strategies and sound policy decisions for the allocation of resources to assist HIV-infected persons. The study will continue to use 6 clinical centers, including Henry Ford Hospital, and a data coordinating center. The study will maintain its cohort and its prospective, longitudinal design for the evaluation of participants grouped by HIV infection status and transmission category, and stratified by numbers of circulating CD-4 (T-helper) lymphocytes. Standardized clinical and laboratory studies, of proven value in detecting pulmonary complications, are systematically applied to detect HIV-associated complications. The results of these tests are correlated with demographic and immunologic data. Additional observations relating to the identification of specific complications such as tuberculosis. Data from all components of the study will be transmitted from the Clinical Centers to the Coordinating Center which will monitor performance of the Clinical Centers as well as provide quality control to assure uniformity of data quality. The Coordinating Center will also provide statistical expertise, in addition to that available from within the Clinical Centers, to facilitate the analysis of study data.

此提交是多中心肺艾滋病的六个 并发症研究（PACS）项目。 我们的主要目的是继续 研究提供有关肺部疾病频率和类型的数据 发生在艾滋病毒感染的人身上，描述该课程和 这些疾病的结果。 将特别关注 识别人口亚组之间的并发症模式 尚未对女性和黑人等进行广泛的研究， 定义艾滋病毒传播组之间的差异。 独特的队列 PACS建立的也将为 对特定并发症的新见解，例如气道疾病和 结核病，允许对新方法进行诊断的测试 结核感染和肺并发症的预测， 可以更好地定义早期肺事件对 艾滋病毒感染及其并发症的后期阶段。 此信息是 制定临床策略和合理政策至关重要 分配资源以协助艾滋病毒感染者的决定。 该研究将继续使用6个临床中心，包括亨利·福特 医院和数据协调中心。 该研究将保持其 队列及其前瞻性，纵向设计用于评估 由HIV感染状况和传播类别分组的参与者， 并按照循环CD-4（T-Helper）淋巴细胞的数量进行分层。 标准化的临床和实验室研究，具有可靠的价值 检测肺并发症，系统地应用 HIV相关并发症。 这些测试的结果相关 具有人口统计学和免疫数据。 有关的其他观察 鉴定特定并发症，例如结核病。 研究的所有组成部分的数据将从 临床中心到协调中心，该中心将监视 临床中心的性能以及为 确保数据质量的统一性。协调中心也将 提供统计专业知识，除了从内部提供 临床中心，以促进研究数据的分析。