NHLBI GROWTH AND HEALTH STUDY EXTENSION

NHLBI 成长和健康研究扩展

• 批准号: 3553542
• 负责人: Bruce A Barton
• 金额: $ 34.67万
• 依托单位: MARYLAND MEDICAL RESEARCH INSTITUTE, INC
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-03 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553542
• 关键词: African American; adolescence (12-20); blood glucose; blood lipid; blood pressure; body composition; body height; body physical activity; body weight; cardiovascular disorder; case history; caucasian American; coping; data collection; diet; disease /disorder proneness /risk; eating; epidemiology; family structure /dynamics; female; health behavior; human puberty; human subject; insulin; longitudinal human study; nutrition related tag; obesity; parent offspring interaction; psychological tests; questionnaires; racial /ethnic difference; self concept; statistics /biometry; stress; tobacco abuse

An extension to the NHLBI Growth and Health Study (NGHS I, HC-55025), a five-year cohort study of the development of obesity and its effects on cardiovascular disease (CVD) risk factors in black and white adolescent females, is proposed to continue tracking the cohort until subjects complete pubertal maturation. the extension is proposed because during NGHS I, when the subjects were ages 9-10 to 13-14 years, race differences in pubertal (physiological) and adolescent (psychological-behavioral) factors observed in the subjects were confounded. During these ages in NGHS I, black girls were more mature at every annual visit. During NGHS I, black girls also had greater between-visit changes (increases) in dietary intake, height, weight, adiposity, and blood pressure. They were taller and heavier at every visit within age strata. Because sexual maturation is itself associated with greater height, weight, and adiposity, behavioral and cultural factors contributing to race differences in weight gain are confounded with maturational differences and identification of behavioral factors is limited. Race differences in anthropometry for girls at baseline, however, were not significant, except for triceps skinfold for which whites were larger. Consequently, NGHS II will follow this cohort of girls until they have completed pubertal maturation. Specifically, NGHS II will measure: 1) antecedent factors believed associated with obesity (food attitudes and patterns, diet, physical activity and exercise patterns, and attitudes towards obesity, and thinness); 2) body habitus (height, weight, adiposity, circumferences and maturation); and 3) CVD risk factor levels (total, HDL and LDL cholesterol, triglycerides, blood pressure, and smoking). We will conduct these studies on the same girls and their parents with whom we have been working successfully for the past 4 1/2 years in NGHS I, following them for three (3) more years until all girls have completed puberty. Thus, NGHS II will provide unique insights in factors associated with the differential increase in weight and adiposity in adolescent females and potentially identify practical interventions.

NHLBI生长和健康研究（NGHS I，HC-55025）的扩展，a 一项为期五年的队列研究，探讨肥胖的发展及其对 黑人和白色青少年心血管疾病（CVD）危险因素 建议继续跟踪队列，直至受试者 青春期完全成熟 之所以提出延期，是因为 NGHS I，当受试者年龄为9-10岁至13-14岁时，种族差异 青春期（生理）和青少年（心理-行为） 在受试者中观察到的因素混杂。 在这些时代， NGHS I，黑人女孩在每年的访问中都更成熟。 在NGHS I期间， 黑人女孩的饮食也有更大的访问之间的变化（增加）， 摄入量、身高、体重、肥胖和血压。 他们更高 年龄层内每次访视时体重都更重。 因为性成熟是 本身与更大的身高，体重和肥胖，行为 造成体重增加的种族差异的文化因素是 与成熟的差异和行为的识别混淆 因素有限。 年龄组女孩人体测量的种族差异 然而，基线没有显著性，除了三头肌皮褶厚度， 哪个白人更大 因此，NGHS II将遵循这一队列， 女孩直到青春期成熟。 具体而言，NGHS II 将测量：1）被认为与肥胖相关的前因因素（食物 态度和模式，饮食，身体活动和锻炼模式，以及 对肥胖和瘦的态度）; 2）体型（身高，体重， 肥胖、周长和成熟）;和3）CVD风险因素水平 （总胆固醇、高密度脂蛋白和低密度脂蛋白胆固醇、甘油三酯、血压和 吸烟）。 我们将对同样的女孩和她们的孩子进行这些研究。 在过去的四年半里，我们与他们成功合作的父母 在NGHS I中，跟踪她们三（3）年以上，直到所有女孩 已经完成了青春期。 因此，NGHS II将提供独特的见解， 与体重和肥胖差异增加相关的因素 并可能确定实际干预措施。