NHLBI GROWTH AND HEALTH STUDY EXTENSION

NHLBI 成长和健康研究扩展

• 批准号: 3553538
• 负责人: JOHN A MORRISON
• 金额: $ 48万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553538
• 关键词: African American; adolescence (12-20); blood chemistry; blood lipid; blood pressure; body composition; body physical activity; cardiovascular disorder; cardiovascular disorder epidemiology; case history; caucasian American; diet; disease /disorder proneness /risk; family; female; health behavior; human puberty; human subject; longitudinal human study; nutrition related tag; obesity; racial /ethnic difference; self concept; socioeconomics; stress

The Cincinnati Clinical Center of the National Heart Lung and Blood Institute's Growth and Health Study (NGHS-I, HC 55025), in conjunction with its collaborating centers, proposes an extension to the current study so that the cohort being followed for five years from ages 9 and 10 years to ages 13 and 14 years can be followed through the entire pubertal period. The goals of the NGHS initiative were to describe and explain a) the greater incidence of obesity in black females during adolescence and b) its association to major cardiovascular disease (CVD) risk factors. The Cincinnati Center, therefore, proposes to measure in the cohort of girls for three more years: 1) antecedent factors (e.g., diet, exercise, and psychosocial factors); 2) body habitus (e.g. height, weight, skinfolds, and circumferences, and maturation status); and 3) CVD risk factors affected by body habitus (e.g. blood pressure and lipids). Parents and guardians of the girls will also be evaluated. The proposed extension is described in detail in the collaborative grant application. The Cincinnati Center has conducted a school-based study in NGHS-I: subjects were enrolled from the fourth and fifth grade classes of public and parochial schools in Cincinnati and surrounding Hamilton County selected from to be racially, geographically, and socioeconomically representative of the area. The Cincinnati Center enrolled 867 students, 430 white and 437 black. At the end of NGHS-I, the girls will be in grades 8 and 9. In the extension (NGHS-II), subjects will be in grades 9-12. The Cincinnati Center proposes to continue a school-based study, though some subjects will have to be seen at Children's Hospital or their home for a variety of reasons (e.g. moving outside the area, but within 100 miles of Cincinnati, transferring to a school which will not cooperate with the study (this has not occurred to date), or dropping out of school.) The Cincinnati Center will continue to use basically the same staff, techniques, and incentives used in NGHS-I. Using these methods, the Cincinnati Center, like its collaborating partners, has achieved an excellent retention rate in the cohort: (89%) were still in the study at the end of Year 4.

国家心肺血液中心辛辛那提临床中心 研究所的增长和健康研究(NGHS-I，HC 55025)，与 它的合作中心，建议对当前的研究进行扩展，因此 从9岁到10岁的队列被跟踪了五年 13岁和14岁可以被跟踪到整个青春期。 NGHS倡议的目标是描述和解释a) 黑人女性青春期肥胖率更高，以及b)其 与主要心血管疾病(CVD)危险因素的关联。这个 因此，辛辛那提中心建议在女孩队列中进行测量 再坚持三年：1)先行因素(例如，饮食、锻炼和 心理社会因素)；2)身体习惯(例如身高、体重、皮褶和 周长和成熟状态)；以及3)影响心血管疾病的危险因素 身体习性(如血压和血脂)。的父母及监护人 这些女孩也将接受评估。建议的扩展在中介绍 详细信息请参阅协作性赠款申请。 辛辛那提中心在NGHS-I中进行了一项校本研究： 受试者来自四年级和五年级的公共班级 以及辛辛那提和周围汉密尔顿县的教区学校 从种族、地理和社会经济上进行选择 该地区的代表。辛辛那提中心招收了867名学生， 430个白人和437个黑人。在NGHS-I结束时，女孩们将进入年级 8和9.在扩展计划(NGHS-II)中，科目将设在9-12年级。这个 辛辛那提中心提议继续一项以学校为基础的研究，尽管有些 受试者将不得不在儿童医院或他们的家中接受治疗 各种原因(例如，搬到该区域之外，但在100英里以内 辛辛那提，转到一所不愿与 学习(到目前为止还没有发生过)，或者辍学。)这个 辛辛那提中心将继续使用基本相同的工作人员， NGHS-I中使用的技术和激励措施。使用这些方法， 辛辛那提中心和它的合作伙伴一样，已经实现了 队列中的优秀保留率：(89%)仍在研究中 第四年末。