LONGITUDINAL LDL-C STUDIES IN BLACK AND WHITE FAMILIES

描述：(改编自《调查者摘要》)浓度升高 血浆低密度脂蛋白胆固醇(LDL-C)是高血压的主要危险因素 冠心病，在家族中有明显的聚集性。此群集具有 在黑人和白人家庭的横断面研究中都观察到了这种现象，但 关于低密度脂蛋白家族聚集性的纵向数据几乎是 根本不存在。拟议的研究将提供新的重要信息 关于黑人和白人家庭低密度脂蛋白-C家族性相关性的变化 从共享家庭环境时代到分居环境时代 家庭，使用普林斯顿脂质研究诊所(LRC)的家庭 流行率(1973-75)和家庭研究(1975-76)。拟议的研究还将 提供有关个人低密度脂蛋白水平变化的重要信息 同样是25年。以前的学生参与者年龄在6岁到18岁之间 年龄，现在32岁到45岁；他们的父母(主要)26岁到55岁 年龄，现在是51岁到80岁。中国人血浆低密度脂蛋白-C浓度 儿童和成人已被证明与载脂蛋白(Apo)有关。 E基因型，肥胖，并有饮食、吸烟等选择性行为 吸烟和体力活动。在LRC的研究中，测量了 低密度脂蛋白胆固醇、身体习性、选择性行为和家族史 心血管疾病(CVD)。拟议的研究将获得重复的措施 这些因素，加上决定载脂蛋白E亚型。个体低密度脂蛋白胆固醇的变化 然后，可以结合以下方面评估水平和家族关系 载脂蛋白E亚型、体成分、选择性行为和家族史 心血管疾病。家庭成员有相同的体重范围，脂肪分布模式， 饮食和吸烟习惯，以及体力活动水平。在多大程度上 载脂蛋白E亚型决定低密度脂蛋白水平的家族聚集性 与相似的肥胖水平和相似的行为相互作用， 目前尚不清楚。调查人员表示，这项研究的数据将 对低密度脂蛋白水平聚集的机制提供新的见解。他们 进一步指出，影响低密度脂蛋白水平长期变化的因素 将被澄清，并理解环境和遗传影响 收获了。他们的结论是，这些信息可以用来改进预测 评估未来的冠心病风险，并制定干预措施。

DESCRIPTION: (Adapted from Investigator's Abstract) Elevated concentrations of plasma low density lipoprotein cholesterol (LDL-C), a major risk factor for coronary heart disease, cluster significantly in families. This clustering has been observed in cross-sectional studies in both black and white families, but longitudinal data on the familial clustering of LDL-C are virtually nonexistent. The proposed study will provide new and important information about changes in the familial LDL-C correlations in black and white families from the period of shared household environments to that of separate households, using families from the Princeton Lipid Research Clinics (LRC) Prevalence (1973-75) and Family Studies (1975-76). The proposed study will also provide important information on changes in individual LDL-C levels over the same 25 year period. The former student participants were six to 18 years of age and are now 32 to 45 years of age; their parents were (largely) 26 to 55 years of age and are now 51 to 80 years of age. Plasma LDL-C concentrations in children and adults have been shown to associate with the apolipoprotein (apo) E genotype, with obesity, and with such elective behaviors as diet, cigarette smoking, and physical activity. In the LRC Study, measurements were made of LDL-C, body habitus, elective behaviors, and the family history of cardiovascular disease (CVD). The proposed study will obtain repeat measures of these factors, plus determine the apo E isoforms. Changes in individual LDL-C levels and in familial associations can then be assessed in association with apo E isoforms, body composition, elective behaviors, and family history of CVD. Family members share ranges of body weight, patterns of fat distribution, dietary and smoking habits, and physical activity levels. The extent to which the familial clustering of LDL-C levels is determined by apo E isoforms interacting with the similar levels of obesity, and with the similar behaviors, is not currently known. The investigators state that data from this study will provide new insights into mechanisms for the clustering of LDL-C levels. They further state that the factors influencing long term changes in LDL-C levels will be clarified and an understanding of environmental and genetic influences gained. They conclude that this information can be used to improve prediction of future CHD risk and to formulate interventions.