LONGITUDINAL LDL-C STUDIES IN BLACK AND WHITE FAMILIES

描述：（改编自研究者摘要） 血浆低密度脂蛋白胆固醇（LDL-C）， 冠心病的家族聚集性显著。这种集群具有 在黑人和白色家庭的横断面研究中观察到， 关于LDL-C家族聚集性的纵向数据实际上是 根本不存在拟议的研究将提供新的重要信息 关于黑人和白色家庭中家族LDL-C相关性的变化 从共享家庭环境的时期到分离的时期， 家庭，使用来自普林斯顿脂质研究诊所（LRC）的家庭 流行率（1973-75年）和家庭研究（1975-76年）。拟议的研究还将 提供了关于个体LDL-C水平变化的重要信息， 同样的25年。以前的学生参与者是6到18岁的 年龄和现在32至45岁;他们的父母（大部分）26至55岁 年龄在51岁到80岁之间。血浆LDL-C浓度 儿童和成人已被证明与载脂蛋白（apo） E基因型，肥胖，饮食、吸烟等选择性行为 吸烟和体力活动。在法改会的研究中， LDL-C、体型、选择性行为和家族史 心血管疾病（CVD）。拟议的研究将获得以下重复测量结果： 这些因素，加上决定载脂蛋白E亚型。个体LDL-C的变化 水平和家庭协会，然后可以评估与 载脂蛋白E亚型、身体组成、选择性行为和家族史 CVD。家庭成员的体重范围，脂肪分布模式， 饮食和吸烟习惯以及身体活动水平。的程度 LDL-C水平的家族聚集性由载脂蛋白E亚型决定 与相似的肥胖程度和相似的行为相互作用， 目前尚不清楚。研究人员指出，这项研究的数据将 为LDL-C水平的聚类机制提供了新的见解。他们 进一步指出，影响LDL-C水平长期变化的因素 将澄清和环境和遗传影响的理解 获得。他们的结论是，这些信息可以用来改善预测 未来冠心病风险的预测和制定干预措施。

DESCRIPTION: (Adapted from Investigator's Abstract) Elevated concentrations of plasma low density lipoprotein cholesterol (LDL-C), a major risk factor for coronary heart disease, cluster significantly in families. This clustering has been observed in cross-sectional studies in both black and white families, but longitudinal data on the familial clustering of LDL-C are virtually nonexistent. The proposed study will provide new and important information about changes in the familial LDL-C correlations in black and white families from the period of shared household environments to that of separate households, using families from the Princeton Lipid Research Clinics (LRC) Prevalence (1973-75) and Family Studies (1975-76). The proposed study will also provide important information on changes in individual LDL-C levels over the same 25 year period. The former student participants were six to 18 years of age and are now 32 to 45 years of age; their parents were (largely) 26 to 55 years of age and are now 51 to 80 years of age. Plasma LDL-C concentrations in children and adults have been shown to associate with the apolipoprotein (apo) E genotype, with obesity, and with such elective behaviors as diet, cigarette smoking, and physical activity. In the LRC Study, measurements were made of LDL-C, body habitus, elective behaviors, and the family history of cardiovascular disease (CVD). The proposed study will obtain repeat measures of these factors, plus determine the apo E isoforms. Changes in individual LDL-C levels and in familial associations can then be assessed in association with apo E isoforms, body composition, elective behaviors, and family history of CVD. Family members share ranges of body weight, patterns of fat distribution, dietary and smoking habits, and physical activity levels. The extent to which the familial clustering of LDL-C levels is determined by apo E isoforms interacting with the similar levels of obesity, and with the similar behaviors, is not currently known. The investigators state that data from this study will provide new insights into mechanisms for the clustering of LDL-C levels. They further state that the factors influencing long term changes in LDL-C levels will be clarified and an understanding of environmental and genetic influences gained. They conclude that this information can be used to improve prediction of future CHD risk and to formulate interventions.