CHORIONIC VILLUS SAMPLING VS AMNIOCENTESIS-DATA CENTER

统计与计算机系生物统计中心 乔治华盛顿大学信息系统学院申请五年制 续签编号5-ULO-HD-19897-05的合作协议 绒毛取样与羊膜穿刺术的对比研究--数据中心 提议继续生物统计中心的数据协调 以下列出的四个主要持续项目的中心活动，以及一个 NICHD关于婴儿日托对儿童发展影响的新研究， 从本年度开始。 我们要求续签的正在进行的主要项目包括： 1.绒毛取样和羊膜穿刺术研究，现已进入最后阶段 两项主要研究的数据收集阶段，目前正在参与 广泛的数据分析活动； 2.孕产妇和胎儿医学股网络，目前正在开展三项工作 临床试验； 3.新生儿重症监护病房网络，目前正在进行两个 临床试验和低出生体重儿登记；以及 4.RADIUS研究，已进入第三年的临床试验。 应用程序的一般部分描述了数据协调中心 适用于所有项目的方法。科学目标，迄今为止的进展， 并给出了为期5年的实验设计和方法。 将特定于每个项目的部分分开。

The Biostatistics Center of the Department of Statistics and Computer Information Systems, George Washington University, requests a five-year renewal of the Cooperative Agreement number 5-UlO-HD-19897-05, "Chorionic Villus Sampling vs. Amniocentesis Study - Data Center". The application proposes a continuation of the Biostatistics Center's Data Coordinating Center activities for four major continuing projects listed below, and a new NICHD study of the effects of infant day care on child development, beginning during the current year. The major ongoing projects for which we request renewal are: 1.The Chorionic Villus Sampling and Amniocentesis Study, now in its final stages of data collection for two major studies, and currently involved in extensive data analysis activities; 2.The Maternal Fetal Medicine Units Network, currently conducting three clinical trials; 3.The Neonatal Intensive Care Units Network, currently conducting two clinical trials and a registry of low birthweight infants; and 4.The RADIUS Study, a clinical trial in its third year. A general section of the application describes data coordinating center methods which apply to all projects. The scientific aims, progress to date, and experimental design and methods for the 5-year period, are given in separate sections specific to each project.