CHORIONIC VILLUS SAMPLING VS AMNIOCENTESIS-DATA CENTER

统计与计算机系生物统计中心 信息系统，乔治华盛顿大学，要求五年 更新合作协议号5-UlO-HD-19897-05，“绒毛膜 绒毛取样与羊膜穿刺术研究-数据中心”。应用 建议继续生物统计中心的数据协调 中心活动的四个主要持续项目如下所列， NICHD关于婴儿日托对儿童发育影响的新研究， 从今年开始。 我们要求延期的正在进行的主要项目是： 1.绒毛膜绒毛取样和羊膜穿刺术研究，目前已进入最后阶段 两项主要研究的数据收集阶段，目前参与了 广泛的数据分析活动; 2.产妇胎儿医疗单位网络，目前正在进行三项 临床试验; 3.新生儿重症监护室网络，目前正在进行两项 低出生体重儿的临床试验和登记;以及 4. RADIUS研究，第三年的临床试验。 应用程序的常规部分介绍了数据协调中心 适用于所有项目的方法。科学目标，迄今为止的进展， 和实验设计和方法，为5年的时间，给出了在 每个项目都有单独的部分。

The Biostatistics Center of the Department of Statistics and Computer Information Systems, George Washington University, requests a five-year renewal of the Cooperative Agreement number 5-UlO-HD-19897-05, "Chorionic Villus Sampling vs. Amniocentesis Study - Data Center". The application proposes a continuation of the Biostatistics Center's Data Coordinating Center activities for four major continuing projects listed below, and a new NICHD study of the effects of infant day care on child development, beginning during the current year. The major ongoing projects for which we request renewal are: 1.The Chorionic Villus Sampling and Amniocentesis Study, now in its final stages of data collection for two major studies, and currently involved in extensive data analysis activities; 2.The Maternal Fetal Medicine Units Network, currently conducting three clinical trials; 3.The Neonatal Intensive Care Units Network, currently conducting two clinical trials and a registry of low birthweight infants; and 4.The RADIUS Study, a clinical trial in its third year. A general section of the application describes data coordinating center methods which apply to all projects. The scientific aims, progress to date, and experimental design and methods for the 5-year period, are given in separate sections specific to each project.