Computational reconstruction and validation of a gene regulatory network controlling differentiation of B cells to antibody-secreting plasma cells

控制 B 细胞向抗体分泌浆细胞分化的基因调控网络的计算重建和验证

• 批准号: nhmrc : 1128609
• 负责人: Dr Melissa Davis
• 金额: $ 42.19万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/computational-reconstruction-validation-plasma-cells/948253
• 关键词: Computational; reconstruction; validation; gene; regulatory

Regulation of B cell differentiation, which occurs when our body responds to antigen infection is tightly controlled by a gene regulatory network. This project will be the first study to reconstruct a regulatory network for this process by using genome-wide expression and transcription factor binding data. The research finding from this study will elucidate the molecular mechanisms regulating this process and will shed new light on how this network is altered in lymphoma and myeloma.

B细胞分化的调节，当我们的身体对抗原感染作出反应时发生，由基因调节网络严格控制。该项目将是第一个通过使用全基因组表达和转录因子结合数据来重建这一过程的调控网络的研究。这项研究的发现将阐明调节这一过程的分子机制，并将为淋巴瘤和骨髓瘤中该网络如何改变提供新的见解。