NHLBI GROWTH AND HEALTH STUDY EXTENSION

NHLBI增长与健康研究(NGHS I，HC-55025)的扩展，a 肥胖发展及其对健康影响的五年队列研究 黑人和白人青少年心血管疾病危险因素的研究 女性，建议继续跟踪队列，直到受试者 青春期完全成熟。之所以提出延期，是因为在 NGHS I，当受试者年龄在9-10岁到13-14岁时，种族差异 青春期(生理)和青春期(心理-行为) 在受试者身上观察到的因素被混淆了。在这些时代里 在每一次的年度访问中，黑人女孩都更加成熟。在NGHS I期间， 黑人女孩在两次访问之间的饮食变化(增加)也更大 摄入量、身高、体重、肥胖和血压。他们长得更高 在不同年龄段的每一次访问中都会变得更重。因为性成熟是 它本身与更高的身高、体重和肥胖症、行为 导致体重增加的种族差异的文化因素有 与成熟的差异和行为认同相混淆 这些因素是有限的。女孩在人体测量方面的种族差异 然而，基线并不显著，除了三头肌皮褶 哪种白色的更大。因此，NGHS II将遵循这一队列 女孩，直到她们完成青春期成熟。具体地说，NGHS II 将测量：1)被认为与肥胖有关的先行因素(食物 态度和模式、饮食、体力活动和锻炼模式，以及 对肥胖和苗条的态度)；2)身体习惯(身高、体重、 肥胖、周长和成熟)；以及3)心血管疾病危险因素水平 (总胆固醇、高密度脂蛋白和低密度脂蛋白、甘油三酯、血压和 吸烟)。我们将对同样的女孩和她们的 在过去的4年半里，我们成功地与他们合作的父母 在NGHS I中呆上几年，再跟随她们三年，直到所有女孩 已经完成了青春期。因此，NGHS II将在以下方面提供独特的见解 与体重和肥胖症差异增加相关的因素 在青春期女性中，并有可能确定实际干预措施。

An extension to the NHLBI Growth and Health Study (NGHS I, HC-55025), a five-year cohort study of the development of obesity and its effects on cardiovascular disease (CVD) risk factors in black and white adolescent females, is proposed to continue tracking the cohort until subjects complete pubertal maturation. the extension is proposed because during NGHS I, when the subjects were ages 9-10 to 13-14 years, race differences in pubertal (physiological) and adolescent (psychological-behavioral) factors observed in the subjects were confounded. During these ages in NGHS I, black girls were more mature at every annual visit. During NGHS I, black girls also had greater between-visit changes (increases) in dietary intake, height, weight, adiposity, and blood pressure. They were taller and heavier at every visit within age strata. Because sexual maturation is itself associated with greater height, weight, and adiposity, behavioral and cultural factors contributing to race differences in weight gain are confounded with maturational differences and identification of behavioral factors is limited. Race differences in anthropometry for girls at baseline, however, were not significant, except for triceps skinfold for which whites were larger. Consequently, NGHS II will follow this cohort of girls until they have completed pubertal maturation. Specifically, NGHS II will measure: 1) antecedent factors believed associated with obesity (food attitudes and patterns, diet, physical activity and exercise patterns, and attitudes towards obesity, and thinness); 2) body habitus (height, weight, adiposity, circumferences and maturation); and 3) CVD risk factor levels (total, HDL and LDL cholesterol, triglycerides, blood pressure, and smoking). We will conduct these studies on the same girls and their parents with whom we have been working successfully for the past 4 1/2 years in NGHS I, following them for three (3) more years until all girls have completed puberty. Thus, NGHS II will provide unique insights in factors associated with the differential increase in weight and adiposity in adolescent females and potentially identify practical interventions.