CANCER AND LEUKEMIA GROUP B

本申请寻求对CALGB活动的支持 通过加州大学参与的调查人员 圣地亚哥医学院和附属机构，位于 癌症和白血病B组的计划在 在即将到来的资助期，我们的目标是做出重大贡献 集团权责发生制、集团科学和集团管理。我们 预计在加强活动的基础上应计额有所增加 在主要成员机构和我们的附属机构，都有一个 今年第一年最低目标是200例确诊病例 申请。我们希望继续为以下方面作出广泛贡献 通过设计和担任主席提高集团的智力生产力 协议，介绍小组验证的试点观察结果，以及 扩张，并通过刺激更多的基础研究组成部分来 小组活动。我们计划继续为集团提供直接服务 通过维护活动单元格表面标记引用 技术素质超高、科学过硬的实验室 复杂性，并使用其中可用的新技术 实验室进一步拓宽群体科学。我们的成员 机构期望继续为集团做出重大贡献 作为主席的科学/行政(西格伦-辐射模式 委员会；约翰逊数据管理委员会；绿色- 呼吸系统疾病委员会)或副主席(Royston- 免疫学委员会)或常设核心委员会成员 集团科学委员会和管理委员会。我们将继续 作为CCOP的临床资源和研究基地 我们的CCOP附属机构在内华达州拉斯维加斯的活动，以及 努力进一步加强我们的临床试验外展 将网络作为一种既能增加收益又能刺激 增强智力活力和最先进的素质 在整个圣地亚哥地区提供整体肿瘤学护理。 对CALGB的持续参与继续发挥着 教职员工、研究员和 加州大学圣地亚哥分校的管家，退伍军人管理局医疗 中心、海军地区医疗中心以及所有 血液学和血液学私人执业的关联参与者 参加我们CALGB活动的内科肿瘤学家。

This application seeks support for the activities of CALGB investigators participating through the University of California San Diego School of Medicine and adjunct institutions, in the programs of the Cancer and Leukemia Group B. During the coming grant period, we aim to make major contributions to Group accrual, Group science, and Group administration. We project some increase in accrual based on enhanced activities both at the main member institution and in our adjuncts, with a minimum goal of 200 accuerd cases in the first year of this application. We expect to continue to contribute extensively to intellectual productivity of the Group by designing and chairing protocols, presenting pilot observations for Group validation and expansion, and by stimulating more basic research components to Group activities. We plan to continue direct service to the Group by maintaining an active Cell Surface Marker Reference Laboratory of exceptionally high technical quality and scientific sophistication, and use new techniques available within that laboratory to further broaden Group science. Members of our institution expect to continue their major contributions to Group science/administration as chairs (Seagren - Radiation Modality Committee; Johnson - Data Management Committee; Green - Respiratory Disease Committee) or vice-chairs (Royston - Immunology Committee) or Core Committee members of standing Group scientific and administrative committees. We will continue to serve as a clinical resource and research base for CCOP activities of our CCOP adjunct in Las Vegas, Nevada, and are working to further strengthen our clinical trials Outreach Network as a means to both increase accrual and stimulate and strengthen the intellectual vitality and state-of-the-art quality of overall oncology care delivered in the entire San Diego area. Ongoing participation in CALGB continues to serve as an important educational vehicle for Faculty, Fellows, and Housestaff at UCSD, the Veterans Administration Medical Center, the Naval Regional Medical Center, as well as for all the affiliated participants in private practice of hematology and medical oncology who share in our CALGB activities.