BIOLOGICAL MARKERS IN TREATMENT OF PROSTATE CANCER

这项提议的目标是继续提供研究和 实验室对国家临床合作试验的核心支持 癌症研究所的国家前列腺癌项目。为了…的目的 质量控制，各参与中心势在必行 有统一的生物标志物，与监测 前列腺癌的治疗和管理，在各种治疗方案。 可以有效地进行客观的临床病理评估 在一个合作组中，只有一组标准的测试和数据。这个 评估将根据临床信息进行，这些信息由 该集团的中央统计局，并从多个实验室测试， 如本提案所提供的，这些内容在 当地或常规的参与医院。血清前列腺特异性 沙门氏菌的抗原、前列腺酸性磷酸酶、骨同工酶和肝脏同工酶 将测定碱性磷酸酶。任何新的生物标志物或化验 程序，这将表明改善和/或附加的临床价值 监测前列腺癌的治疗反应，可以添加到 可用时的测试面板。计算机辅助统计 技术，如考克斯模型和逻辑模型等，将是 用于系统、客观的临床实验室分析。 此外，建立和清点前列腺血清库 癌症将被仔细维护并进一步扩大。这个血清库 代表一个国家的资源。这项续期建议的目的是 继续发挥这个中心实验室的核心职能，这是一个 主要组成部分，并在继续取得成功方面发挥了不可或缺的作用 关于前列腺癌的重大合作临床试验在 由国家癌症研究所赞助。

The objective of this proposal is to continue to provide research and laboratory core support to the Cooperative Clinical Trials of the National Cancer Institute's National Prostatic Cancer Project. For purpose of quality control, it is imperative for the various participating centers to have uniform biological markers, relevant to monitoring the efficacy of prostate cancer treatment and management, in various treatment protocols. An objective clinical pathological evaluation can be performed effectively in a cooperative group only from a standard set of tests and data. The evaluation will be carried out from clinical information compiled at the Central Statistics Office of the group, and from multiple laboratory tests, as provided by this proposal, that are not readily available in participating hospitals locally or routinely. Serum prostate-specific antigen, prostatic acid phosphatase, bone isoenzyme and liver isoenzyme of alkaline phosphatase will be measured. Any new biomarkers or assay procedures, which will indicate improved and/or additive clinical value in monitoring the treatment response of prostate cancer, can be added to the panel of tests as they become available. Computer-assisted statistical techniques, e.g. the Cox model and logistic model, among others, will be used for systematic and objective clinical-laboratory analysis. Additionally, establishment and inventory of a serum bank of prostate cancer will be carefully maintained and further expanded. This serum bank represents a national resource. The purpose of this renewal proposal is to continue the core function of this central laboratory, which has been a major component and has played as essential role in the continued success of the major cooperative clinical trial on prostate cancer under the auspices of the National Cancer Institute.