ESTABLISHMENT OF A BREEDING AND RESEARCH PROGRAM

建立育种和研究计划

• 批准号: 3563757
• 负责人: RICHARD SWENSON
• 金额: $ 50.62万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 1990-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3563757
• 关键词: animal population genetics; artificial fertilization; building /facility design /renovation

We propose to establish a dedicated breeding colony of chimpanzees (Pan troglodytes) that will produce between 10 and 14 healthy and behaviorally normal offspring per year. These offspring will be used to establish a stable, self-sustaining breeding population of chimpanzees that will guarantee the future availability of these animals for biomedical and behavioral research and testing. We propose to conduct the breeding program utilizing an existing stable social group of chimpanzees, pair matings using known breeder animals and artificial insemination of females that do not breed spontaneously. Infants will be managed in such a way as to maximize social experience, including extensive mother-rearing where possible, peer group-rearing when nursery care is required and fostering of nursery-reared infants onto competent mothers. We also propose to conduct research in areas that will promote improved reproductive success and efficiency and improved behavioral outcome. This research will include investigation of early detection of labor using telemetry to allow early and effective assistance when required and thus improve neonatal survival; investigation of hormonal manipulation to shorten interbirth intervals without the need to separate infants from their mothers; methods of gamete preservation to improve artificial breeding techniques and permit maintenance of genetic lines and to promote genetic diversity; and investigation of early rearing techniques in order to develop techniques that are conducive to subsequent successful reproduction and to identify behaviors that are predictive of future reproductive performance.

我们建议建立一个专门的黑猩猩繁育群体(潘 将产生10到14个健康和行为 每年生下正常的后代。这些后代将被用来建立一个 稳定、自给自足的黑猩猩繁殖种群 保证未来这些动物可用于生物医学和 行为研究和测试。我们建议进行繁殖 计划利用现有的稳定的黑猩猩群体，配对 利用已知的繁殖动物进行交配和雌性的人工授精 它们不会自发繁殖。婴儿将以这样的方式进行管理 为了最大限度地增加社会经验，包括广泛的母亲养育， 在需要托儿所的情况下，可能的同龄人群体养育，并培养 把养育的婴儿交给称职的母亲。 我们还建议在将促进改进的领域进行研究 生殖成功和效率以及改善的行为结果。这 研究将包括对使用劳工的早期发现进行调查 遥测，以便在需要时提供早期和有效的协助，因此 提高新生儿存活率；激素调节研究 缩短分娩间隔，无需将婴儿与 他们的母亲；配子保存的方法，以改进人工 育种技术和许可遗传系的维护和推广 遗传多样性；按顺序研究早期饲养技术 开发有助于后续成功的技术 繁殖和识别可预测未来的行为 生殖性能。