ESTABLISHMENT OF A BREEDING AND RESEARCH PROGRAM

建立育种和研究计划

• 批准号: 3560646
• 负责人: RICHARD SWENSON
• 金额: $ 100.89万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 1990-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3560646
• 关键词: animal population genetics; artificial fertilization

We propose to establish a dedicated breeding colony of chimpanzees (Pan troglodytes) that will produce between 10 and 14 healthy and behaviorally normal offspring per year. These offspring will be used to establish a stable, self-sustaining breeding population of chimpanzees that will guarantee the future availability of these animals for biomedical and behavioral research and testing. We propose to conduct the breeding program utilizing an existing stable social group of chimpanzees, pair matings using known breeder animals and artificial insemination of females that do not breed spontaneously. Infants will be managed in such a way as to maximize social experience, including extensive mother-rearing where possible, peer group-rearing when nursery care is required and fostering of nursery-reared infants onto competent mothers. We also propose to conduct research in areas that will promote improved reproductive success and efficiency and improved behavioral outcome. This research will include investigation of early detection of labor using telemetry to allow early and effective assistance when required and thus improve neonatal survival; investigation of hormonal manipulation to shorten interbirth intervals without the need to separate infants from their mothers; methods of gamete preservation to improve artificial breeding techniques and permit maintenance of genetic lines and to promote genetic diversity; and investigation of early rearing techniques in order to develop techniques that are conducive to subsequent successful reproduction and to identify behaviors that are predictive of future reproductive performance.

我们建议建立一个专门的黑猩猩繁殖地（潘 troglodytes），将产生10至14个健康和行为 正常的后代。 这些后代将被用来建立一个 稳定的、自我维持的黑猩猩繁殖种群， 保证这些动物未来可用于生物医学， 行为研究和测试。 我们建议进行繁殖 利用现有的稳定的黑猩猩社会群体，对 使用已知的繁殖动物进行交配和对雌性动物进行人工授精 它们不会自发繁殖 婴儿将以这样的方式管理， 最大化社会经验，包括广泛的母亲养育， 可能的，同龄人群体抚养时，托儿所护理是必要的，并培养 把托儿所养育的婴儿交给称职的母亲。 我们还建议在促进改善的领域进行研究， 繁殖成功和效率以及改善的行为结果。 这 研究将包括调查早期发现的劳动使用 遥测技术，以便在需要时提供早期和有效的援助， 提高新生儿存活率;激素调控研究， 缩短出生间隔，无需将婴儿与 保存配子以提高人工授精效果的方法 育种技术和允许保持遗传品系，并促进 遗传多样性;以及调查早期饲养技术， 开发有助于后续成功的技术， 繁殖和识别预测未来的行为 繁殖性能