A Multimodal Mass Spectrometric Imaging Instrument with Enhanced Ion Characterisation Capability

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This challenge led community project has a clear mission to create new mass spectrometry instrumentation for sensitive, rapid and spatially resolved detection and structural characterisation of exogenous and endogenous compounds from complex samples (e.g. prokaryotic and eukaryotic cells and tissues). The new instruments will include novel multi-modal ion sources with post-desorption ionisation, coupled to a configuration of mass analysers, designed to deliver the highest accuracy and selectivity, which has not been attempted or achieved before. We will construct a unique multimodal imaging mass spectrometer instrument, which allows the molecular mapping of biological tissues at unprecedented sensitivity, chemical depth and spatial resolution. The main instrument modules include a Fourier-transform Ion Cyclotron Resonance spectrometer and hybrid trapped ion mobility-high-resolution time-of-flight mass analyser (instrument 1), a secondary ion mass spectrometer with post-ionisation (instrument 2), and a microscope mode SIMS instrument (instrument 3). To develop the components to deliver this we have designed seven collaborative projects, hosted at partners sites Imperial College London, Oxford, Birmingham and Manchester supported by collaborations with partner institutes Leeds and Edinburgh and collaborating partners Bruker, Ionoptika, NPL and AstraZeneca.