CHARACTERIZATION AND REGULATION OF RELEASE OF ATRIAL NATRIURETIC PEPTIDES

心房钠尿肽释放的表征和调节

基本信息

项目摘要

Cardiac atria contain a family of peptides, collectively termed atrial natriuretic peptides (ANPs), which are derived from a common precursor and possess intrinsic natriuretic, diuretic, vasorelaxant and endocrine modulatory effects. Furthermore, recent immunocytochemical and radioimmunoassay (RIA) distribution studies have localized ANPs to areas of the CNS that suggest the ANPs are involved in central cardiovascular regulatory events and in the release and/or synthesis of certain pituitary gland hormones. Findings revealed the presence of at least two plasma forms of ANP ranging from 24-28 amino acids. Additional studies revealed that volume loading or pressor agents (e.g. adrenaline, vasopressin) which cause atrial stretch result in a rapid increase in circulating ANPs. The acute administration of ethanol to rats in order to achieve blood ethanol levels in the range of .2-.25% did not alter plasma levels of ANPs or vasopressin; however, chronic exposure of rats to ethanol vapors for 7-14 days lowered plasma ANP levels. On the basis of results obtained in vitro from cultured adult rat atrial cardiocytes, it would appear that our observed enhancement of ANPs in vivo are indirectly mediated since a number of pressor agents did not alter ANP secretion in vitro. To date only drugs or experimental conditions which alter intracellular Ca++ levels appear to modulate ANP secretion in cultured atrial myocytes.
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项目成果

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R ESKAY其他文献

R ESKAY的其他文献

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{{ truncateString('R ESKAY', 18)}}的其他基金

PKC AND THE SECRETION AND BIOSYNTHESIS OF NEUROPEPTIDES IN ATT-20 CELLS
PKC 与 ATT-20 细胞中神经肽的分泌和生物合成
  • 批准号:
    4687741
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PKC AND THE SECRETION AND BIOSYNTHESIS OF NEUROPEPTIDES IN ATT-20 CELLS
PKC 与 ATT-20 细胞中神经肽的分泌和生物合成
  • 批准号:
    3822977
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
INFLUENCE OF ETHANOL AND GLUCOCORTICOIDS ON GABA RECEPTORS IN THE CNS
乙醇和糖皮质激素对中枢神经系统 GABA 受体的影响
  • 批准号:
    4687730
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
ETHANOL-INDUCED CHANGES IN B-ENDORPHIN AND CRF BINDING TO PERIPHERAL TISSUE
乙醇引起的 B-内啡肽和 CRF 与外周组织结合的变化
  • 批准号:
    4687731
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
CHARACTERIZATION AND REGULATION OF RELEASE OF ATRIAL NATRIURETIC PEPTIDES
心房钠尿肽释放的表征和调节
  • 批准号:
    3822976
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PKC AND THE SECRETION AND BIOSYNTHESIS OF NEUROPEPTIDES IN ATT-20 CELLS
PKC 与 ATT-20 细胞中神经肽的分泌和生物合成
  • 批准号:
    3821251
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
CNS SEROTONIN AND THE REGULATION OF PERIPHERAL GLUCOSE METABOLISM
中枢神经系统血清素与外周葡萄糖代谢的调节
  • 批准号:
    3745213
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
THE EFFECT OF ETHANOL ON CYCLIC AMP AND BETA-ENDORPHIN RELEASE FROM ATT-20 CELLS
乙醇对 ATT-20 细胞环磷酸腺苷和 β-内啡肽释放的影响
  • 批准号:
    4687739
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
STRESS AXIS, IMMUNE SYSTEM-DERIVED CYTOKINES AND ETHANOL
应激轴、免疫系统衍生的细胞因子和乙醇
  • 批准号:
    3745246
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
CNS SEROTONIN, REGULATION OF PERIPHERAL GLUCOSE METABOLISM
中枢神经系统血清素,外周葡萄糖代谢的调节
  • 批准号:
    3789509
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
心钠素和心脏代谢健康的调节:基因型引导的人类生理学研究
  • 批准号:
    10627996
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    2022
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    --
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Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
心钠素和心脏代谢健康的调节:基因型引导的人类生理学研究
  • 批准号:
    10419574
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    2022
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Mitochondria-mediated effects and therapeutic potential of Atrial Natriuretic Peptide in salt-sensitive hypertension
心房钠尿肽在盐敏感性高血压中的线粒体介导作用和治疗潜力
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    10676800
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    2020
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    --
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Mitochondria-mediated effects and therapeutic potential of Atrial Natriuretic Peptide in salt-sensitive hypertension
心房钠尿肽在盐敏感性高血压中的线粒体介导作用和治疗潜力
  • 批准号:
    10442162
  • 财政年份:
    2020
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    --
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Mitochondria-Mediated Effects and Therapeutic Potential of Atrial Natriuretic Peptide in Salt-Sensitive Hypertension Diversity Supplement
盐敏感性高血压多样性补充剂中心房钠尿肽的线粒体介导作用和治疗潜力
  • 批准号:
    10337412
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    2020
  • 资助金额:
    --
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Mitochondria-mediated effects and therapeutic potential of Atrial Natriuretic Peptide in salt-sensitive hypertension
心房钠尿肽在盐敏感性高血压中的线粒体介导作用和治疗潜力
  • 批准号:
    10472035
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    2020
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Development of a high-precision diagnostic method for heart failure utilizing abnormal biosynthesis of beta-atrial natriuretic peptide in the failing heart
利用衰竭心脏中β-心房钠尿肽的异常生物合成开发心力衰竭的高精度诊断方法
  • 批准号:
    20K08414
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    2020
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    --
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Atrial natriuretic peptide induces peroxisome proliferator
心钠素诱导过氧化物酶体增殖
  • 批准号:
    15K10206
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Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.
心房钠尿肽可防止癌症通过血管内皮细胞转移。
  • 批准号:
    26461393
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    2014
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    --
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Novel strategy for heart failure treatment with recombinant atrial natriuretic peptide-induced cardiac progenitor cells
重组心钠素诱导的心脏祖细胞治疗心力衰竭的新策略
  • 批准号:
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