COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK

关于研究克罗米芬对小鼠生育力影响的建议 普通的骑自行车的女人。克罗米芬被广泛用于刺激生育。AS 在网络的RFA中指出，此处理在没有 评估疗效的标准数据，通常没有确定的诊断 而且耗费了时间、心理储备和金钱。事实上, 有证据表明，克罗米芬实际上可能会损害生育能力； 因此，将其用于治疗在边缘地区可能适得其反。 案子。我们建议研究正常志愿者(定义为长达7个月 在没有怀孕的情况下进行无保护性行为)，以便建立规范性 妊娠率的数据，并评估克罗米芬治疗的效果 关于怀孕率。实验方案构建在 随机、双盲交叉模型。将获得规范的数据 在“毒品清洗”和安慰剂时期。这项研究具有特殊的 RFA在争取其对诊断的直接适用性方面的相关性 和治疗不孕不育，常见但未经证实的用法 克罗米芬在这些条件下，以及研究人群的必要性 最好的办法是通过合作网络获得。

A proposal to study the effects of clomiphene citrate on fertility in normal cycling women. Clomiphene is widely used to stimulate fertility. As indicated in the RFA for the Network, this treatment is applied without normative data for evaluating efficacy, often without established diagnoses and is expensive of time, psychological reserves and money. In fact, evidence indicates that clomiphene may actually impair fertility; therefore, its use for treatment may be counter-productive in marginal cases. We propose to study normal volunteers (defined as up to 7 months unprotected intercourse without pregnancy) in order to establish normative data for pregnancy rates, and to assess the effect of clomiphene treatment on the pregnancy rate. The experimental protocol is constructed upon the randomized, double-blind crossover model. Normative data will be obtained during the "drug washout" and placebo periods. This study has particular relevance for the RFA in fight of its direct applicability to the diagnosis and treatment of infertility, the common but unsubstantiated usage of clomiphene under these conditions, and the need for a study population which can best be obtained through the Cooperative Network.