EFFECTS OF CLOMIPHENE CITRATE ON THE UTERINE ENDOMETRIUM IN MACAQUES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clomiphene citrate (CC) is the most commonly used anti-estrogen for treating infertility in women. Although CC is successful at inducing ovulation, the number of pregnancies achieved is much lower than expected. It is hypothesized that CC exerts negative effects on the uterine endometrium that impair implantation. A pre-clinical study is underway to test whether CC has anti-estrogenic effects on the primate endometrium. This study will prospectively determine whether CC alters the morphological, histological and biochemical characteristics of the endometrium during the follicular and luteal phases of the menstrual cycle in female rhesus monkeys. If such alterations are observed in the nonhuman primate endometrium, new compounds with a more tissue-specific mechanism of action will be evaluated. Development of novel agents that are effective for ovulation induction, but without adverse effects on the uterus, will aid in ameliorating infertility in women.