EFFECTS OF CLOMIPHENE CITRATE ON THE UTERINE ENDOMETRIUM IN MACAQUES

克罗米芬柠檬酸盐对猕猴子宫内膜的影响

• 批准号: 7561981
• 负责人: Mary B Zelinski
• 金额: $ 7.59万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561981
• 关键词: Adverse effects; Biochemical; Characteristics; Clomiphene Citrate; Computer Retrieval of Information on Scientific Projects Database; Development; Endometrium; Estrogen Antagonists; Female; Funding; Grant; Infertility; Institution; Luteal Phase; Macaca; Macaca mulatta; Numbers; Ovulation; Ovulation Induction; Pregnancy; Primates; Research; Research Personnel; Resources; Source; Testing; Tissues; United States National Institutes of Health; Uterus; Woman; implantation; nonhuman primate; novel; preclinical study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clomiphene citrate (CC) is the most commonly used anti-estrogen for treating infertility in women. Although CC is successful at inducing ovulation, the number of pregnancies achieved is much lower than expected. It is hypothesized that CC exerts negative effects on the uterine endometrium that impair implantation. A pre-clinical study is underway to test whether CC has anti-estrogenic effects on the primate endometrium. This study will prospectively determine whether CC alters the morphological, histological and biochemical characteristics of the endometrium during the follicular and luteal phases of the menstrual cycle in female rhesus monkeys. If such alterations are observed in the nonhuman primate endometrium, new compounds with a more tissue-specific mechanism of action will be evaluated. Development of novel agents that are effective for ovulation induction, but without adverse effects on the uterus, will aid in ameliorating infertility in women.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 克罗米芬（CC）是治疗女性不孕症最常用的抗雌激素药物。 虽然CC在诱导排卵方面是成功的，但获得的怀孕数量远低于预期。 据推测，CC对子宫内膜产生负面影响，损害着床。 一项临床前研究正在进行中，以测试CC是否对灵长类动物子宫内膜具有抗雌激素作用。 本研究将前瞻性地确定CC是否改变雌性恒河猴月经周期卵泡期和黄体期子宫内膜的形态学、组织学和生化特征。 如果在非人灵长类动物子宫内膜中观察到此类改变，则将评价具有更组织特异性作用机制的新化合物。 开发有效诱导排卵但对子宫无不良影响的新药物将有助于改善妇女不孕症。