CLINICAL IMMUNE SURVEY OF THE LONGITUDINAL PROJECT PARTICIPANTS

这些研究使用了巴尔的摩老龄化纵向研究的参与者 深入了解遗传、生化和分子机制 潜在的与年龄相关的免疫功能变化。GRANT=Z01AG00120 《美国国家癌症杂志》可获得数据的纵向分析 研究所的监测、流行病学和最终结果(SEER)计划 显示与年龄相关的原发恶性肿瘤发病率上升 1973年至1985年间，美国老年人的脑瘤。 制定了改进恶性脑肿瘤治疗的策略 肿瘤。一种新型亲油性抗癌烷基化试剂--叔丁基 研制了百菌清的酯类化合物。抗胆碱酯酶药物被开发出来 用于治疗阿尔茨海默氏症。可逆过程中的机制 血脑屏障的渗透性开放用于脑治疗 详述。对长春花碱的脑血管渗透性低， 长春新碱和长春花碱已被证实与甾体有关 血脑屏障的障碍。大鼠脑内药代动力学研究 对烷基化抗癌药物环磷酰胺进行了定量。 带正电的蛋白质被证明从血液中被吸收到大脑。 通过受体介导的细胞转运，可作为药物载体。

These studies use participants in the Baltimore Longitudinal Study of Aging to gain insight into the genetic, biochemical and molecular mechanisms underlying age-associated changes in immune function. Grant=Z01AG00120 Longitudinal analysis of available data from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program demonstrated a rise in the age-specific incidence of primary malignant brain tumors in the elderly between 1973 and 1985, in the United States. Strategies were developed to improve the treatment of malignant brain tumors. A novel lipophilic anticancer alkylating agent, a tertiarly butyl ester of chlorambucil, was developed. Anticholinesteroses were developed for treatment of Alzheimer's disease. The mechanism involved in reversible osmotic opening of the blood-brain barrier for brain therapy was elaborated. Low cerebrovascular permeability to vinca alkaloids, vincristine and vinblastine, was demonstrated and related to steric hindrance at the blood brain barrier. Brain pharmacokinetics of cyclophosphamide an alkylating anticancer drug, were quantified. Positively charged proteins were shown to be taken up from blood into brain via receptor mediated transcytosis, and may be used as drug carriers.