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THE STRUCTURE DETERMINATION OF AIDS GLYCOPROTEIN FRAGMENTS

THE STRUCTURE DETERMINATION OF AIDS GLYCOPROTEIN FRAGMENTS
艾滋病糖蛋白片段的结构测定
批准号：
3896413
负责人：
B R BROOKS
金额：
$0.0万
依托单位：
CENTER FOR INFORMATION TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3896413
关键词：
AIDS AIDS therapy X ray crystallography antiAIDS agent antiviral agents chemical models computer assisted sequence analysis computer graphics /printing computer simulation drug design /synthesis /production glycoproteins human immunodeficiency virus 1 nuclear magnetic resonance spectroscopy protein sequence protein structure viral vaccines virus antigen virus envelope

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中文摘要
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英文摘要
We are now actively involved with the intramural effort to develop an antiviral agent for AIDS. Our initial published work has focused on the threedimensional structure determination of selected portions of the surface glycoproteins GPI20 and GP41. The work performed to date proposes possible structures for the amphipathic segments of the HIV-1 gp4l envelope protein, and may have implications for current vaccine development efforts. Our results suggest a possible mechanism for the cytopathic effects of the gpl2O-gp4l complex. We still await further experimental data from NMR or from X-ray crystallography to support further efforts in designing an antiviral agent for this potential target region.
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会议论文
DEVELOPMENT OF THEORETICAL METHODS FOR STUDYING BIOLOGICAL MACROMOLECULES
MOLECULAR DYNAMICS SIMULATIONS OF BIOLOGICAL MACROMOLECULES
DEVELOPMENT OF ADVANCED COMPUTER HARDWARE AND SOFTWARE
MOLECULAR DYNAMICS SIMULATIONS OF BIOLOGICAL MACROMOLECULES
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