THE STRUCTURE DETERMINATION OF AIDS GLYCOPROTEIN FRAGMENTS

艾滋病糖蛋白片段的结构测定

• 批准号: 3896413
• 负责人: B R BROOKS
• 金额: --
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3896413
• 关键词: AIDS; AIDS therapy; X ray crystallography; antiAIDS agent; antiviral agents; chemical models; computer assisted sequence analysis; computer graphics /printing; computer simulation; drug design /synthesis /production; glycoproteins; human immunodeficiency virus 1; nuclear magnetic resonance spectroscopy; protein sequence; protein structure; viral vaccines; virus antigen; virus envelope

We are now actively involved with the intramural effort to develop an antiviral agent for AIDS. Our initial published work has focused on the threedimensional structure determination of selected portions of the surface glycoproteins GPI20 and GP41. The work performed to date proposes possible structures for the amphipathic segments of the HIV-1 gp4l envelope protein, and may have implications for current vaccine development efforts. Our results suggest a possible mechanism for the cytopathic effects of the gpl2O-gp4l complex. We still await further experimental data from NMR or from X-ray crystallography to support further efforts in designing an antiviral agent for this potential target region.

我们现在积极参与校内工作，以开发 艾滋病的抗病毒剂。我们最初发表的工作重点是 选定部分的三维结构测定 表面糖蛋白 GPI20 和 GP41。迄今为止所做的工作建议 HIV-1 gp4l 两亲片段的可能结构 包膜蛋白，可能对当前的疫苗产生影响 发展努力。我们的结果提出了一种可能的机制 gp12O-gp4l 复合物的细胞病变作用。我们还等待进一步 来自 NMR 或 X 射线晶体学的实验数据支持 进一步努力为这一潜在目标设计抗病毒药物 地区。