BIOBEHAVIORAL CONTROL OF CHEMOTHERAPY SIDE EFFECT

这项申请提出了临床心理学家的研究进展 对控制化疗副作用有兴趣和专业知识 使用生物行为方法。 预见性神经过敏和呕吐是会产生的严重副作用。 在接受化疗的患者中，约有25% 癌症。来自心理学、药理学和 神经学检查表明，预见性恶心/呕吐 习得的或习得的行为。充分控制化疗方 预见性恶心和呕吐等影响是必要的 最大限度地提高癌症治疗效果。 建议的研究旨在优化现有的可用资源 控制副作用的行为干预，开发一种新的 用于恶心评估的技术和对副作用的更多了解 影响病因学。 为实现这些目标，设计了以下职业发展活动 为了加强对副作用控制的系统、综合研究 建议：(1)随机临床试验，以评估 系统脱敏的生物行为治疗在以下情况下同样有效 由肿瘤学家和肿瘤科护士完成，当行为学完成时 心理学家；(2)活动生理学的发展和完善 监测患者报告的恶心伴随症状；以及(3)预期 预见性副反应的病因学研究 一种包含8个问题的筛查工具，在患者第一次 化疗对预见侧发展的预测作用 效果。 这项研究预测了长期的利益在改善 患者对当前治疗和随机治疗的依从性 研究试验。

This application proposes research development of a clinical psychologist with interests and expertise in the control of chemotherapy side effects using a biobehavioral approach. Anticipatory neusea and vomiting are significant side effects that develop in approximately 25% of patients receiving chemotherapy treatment for cancer. Converging lines of evidence from psychologic, pharmacologic and neurologic investigations suggest that anticipatory nausea/vomiting are learned or conditioned behaviors. Adequate control of chemotherapy side effects such as anticipatory nausea and vomiting is essential for maximizing cancer treatment effectiveness. Proposed research is directed toward optimizing currently available behavioral interventions for side effect control, developing a new technology for nausea assessment and an increased understanding of side effect etiology. To achieve these aims, the following career development activities designed to enhance systematic, integrated studies of side effect control are proposed: (1) randomized clinical trials to assess whether the biobehavioral treatment of systematic desensitization is as effective when done by oncologists and oncology nurses as it is when done by behavioral psychologists; (2) development and refinement of ambulatory physiologic monitoring for concomitants of patient-reported nausea; and (3) prospective studies on the etiology of anticipatory side effects to test the ability of an 8-question screening instrument given after a patient's first chemotherapy treatment to predict the development of anticipatory side effects. The research has anticipated long-term benefits in the improvement of patient compliance for both current treatment and randomized treatment research trials.